Omega-3 Fatty Acids and Cardiovascular Diseases / UNI-MED Science (PDF)
(Sprache: Englisch)
Renowned world experts in the field of omega-3 fatty acids in cardiology have joined efforts to write a book on "Omega-3 Fatty Acids and Cardiovascular Diseases". The result is a book that condenses the complete relevant scientific knowledge in early 2010....
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Renowned world experts in the field of omega-3 fatty acids in cardiology have joined efforts to write a book on "Omega-3 Fatty Acids and Cardiovascular Diseases". The result is a book that condenses the complete relevant scientific knowledge in early 2010. Scientifically correct, readable, up-to-date, and up to current data, the book renders a difficult area understandably. This wealth of information cannot be found in review articles in journals or any other current source. For years to come, this book will be an important reference for everybody interested in the effects of omega-3 fatty acids on cardiovascular disease.
Inhaltsverzeichnis zu „Omega-3 Fatty Acids and Cardiovascular Diseases / UNI-MED Science (PDF)“
1. Prevention of cardiovascular disease - what can we learn from epidemiology? 10 1.1. Assessment of exposure to omega-3 fatty acids 10 1.2. Fatal and non-fatal myocardial infarction 11 1.2.1. Conventional risk factors, genes and diet 12 1.3. Sudden cardiac death (SCD) 13 1.4. Stroke 14 1.5. Evidence for an increase in other diseases? 15 1.6. Conclusions 15 1.7. References 15 2. Mechanisms of action of omega-3 fatty acids 18 2.1. Effects on cardiac rhythm 18 2.1.1. Mechanisms of action 18 2.1.2. Animal studies 18 2.1.3. Studies in humans on surrogate parameters 18 2.1.4. Supraventricular arrhythmias, especially atrial fibrillation 19 2.1.5. Ventricular arrhythmias and sudden cardiac death 19 2.1.6. Pro-arrhythmic effects? 20 2.1.7. Role of the omega-3 index 20 2.1.8. Conclusion 20 2.1.9. References 21 2.2. Omega-3 fatty acids and inflammatory processes in the context of cardiovascular disease 23 2.2.1. Inflammation 23 2.2.2. Atherosclerosis is an inflammatory disease 23 2.2.3. Fatty acid composition of human inflammatory cells and its modification by marine n-3 fatty acids 26 2.2.4. Changing membrane phospholipid fatty acids can impact on inflammatory cell function 27 2.2.5. Lipid mediators: biosynthesis, roles in inflammation, and the impact of n-3 fatty acids 27 2.2.5.1. Eicosanoids generated from arachidonic acid 27 2.2.5.2. Fatty acid modification of eicosanoid profiles 27 2.2.5.3. Resolvins: Novel anti-inflammatory and inflammation resolving mediators produced from EPA and DHA 28 2.2.6. Influence of n-3 fatty acids on leukocyte chemotaxis 28 2.2.7. Influence of n-3 PUFAs on adhesion molecules and adhesive interactions 29 2.2.8. Influence of n-3 fatty acids on inflammatory cytokines 29 2.2.8.1. Transcription factors involved in regulating inflammatory gene expression 29 2.2.8.2. Fatty acid modulation of inflammatory cytokine production and of transcription factor activation 29 2.2.9. Anti-inflammatory effects of n-3 PUFAs in the context of cardiovascular
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disease 30 2.2.10. Summary and conclusions 30 2.2.11. References 31 2.3. Omega-3 fatty acids in the treatment of dyslipidemia 33 2.3.1. Omega-3 fatty acids and very low density lipoproteins 34 2.3.2. Forms of hypertriglyceridemia responding to omega-3 fatty acids 34 2.3.3. Combination therapy with statins 35 2.3.4. Omega-3 fatty acids and low density lipoproteins 35 2.3.5. Omega-3 fatty acids and high density lipoproteins 35 2.3.6. Fish oil supplements vs. prescription omega-3 products 35 2.3.7. Other cardioprotective effects of omega-3 fatty acids 36 2.3.8. Conclusion 37 2.3.9. References 37 3. Large clinical trials in patients with coronary artery disease or equivalent risk 40 3.1. Method 40 3.2. Intermediate parameters 40 3.3. Studies with clinical endpoints 41 3.4. Meta-analyses and systematic reviews 43 3.5. Meta-analyses of clinical trials in persons with equivalent risk 45 3.6. The omega-3 index and trial results 46 3.7. Conclusion 46 3.8. References 46 4. Clinical trials in heart failure patients 50 4.1. GISSI-HF 50 4.2. References 56 5. Ongoing trials with omega-3 fatty acids 60 5.1. Method 60 5.2. Discussion 60 5.3. References 66 6. The omega-3 index in clinical research and medicine 68 6.1. The omega-3 index - causal link and clinical utility 69 6.2. Impact of the omega-3 index on the design of randomized intervention trials 73 6.3. Drop outs and drop ins 74 6.4. Conclusion 76 6.5. References 76 Index 79
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Bibliographische Angaben
- Autor: Clemens von Schacky
- 2010, 1. Auflage, 81 Seiten, Englisch
- Verlag: Uni-Med Verlag Ag
- ISBN-10: 3837452131
- ISBN-13: 9783837452136
- Erscheinungsdatum: 22.05.2010
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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