Free Radicals in ENT Pathology / Oxidative Stress in Applied Basic Research and Clinical Practice (PDF)
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This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and "white paper" that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.
Dr. Colleen Le Prell is an Associate Professor in the Department of Speech, Language, and Hearing Sciences at the University of Florida. She received her doctorate in Psychology (Biospsychology area) from the University of Michigan followed by post-doctoral studies at the Kresge Hearing Research Institute. Her post-doctoral research emphasized the pharmacology of the inner ear, and was funded by a National Research Service Award from the National Institutes of Health. Current research programs in her laboratory at the University of Florida continue her long-term efforts to precisely characterize the influence of the lateral olivocochlear neurons on auditory nerve function, and extend a collaborative translational research program directed at prevention of acquired hearing loss, including hearing loss induced by exposure to loud sound. She has presented her research findings nationally and internationally, and has lectured on the challenges of translational research in Otolaryngology including a short
Dr. Leonard P. Rybak is a Professor in the Department of Surgery at Southern Illinois University School of Medicine. He received his medical degree from the Medical College of Wisconsin-Milwaukee and completed his internship at Hennepin County Medical Center in Minneapolis. He completed a residency in otolaryngology and also obtained a Ph.D. at the University of Minnesota-Minneapolis. Prior to coming to the SIU School of Medicine, he was an Assistant Professor of Otolaryngology at the University of Minnesota. Dr. Rybak's research interests include growth of cochlear hair cells derived from Immortomouse (HEI-OC1, OC-k3 cells) in culture and mechanisms controlling free radical production within the cochlea.
- 2015, 2015, 507 Seiten, Englisch
- Herausgegeben: Josef Miller, Colleen G. Le Prell, Leonard Rybak
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319134736
- ISBN-13: 9783319134734
- Erscheinungsdatum: 30.04.2015
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- Größe: 9.86 MB
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