PNH and the GPI-Linked Proteins (PDF)
(Sprache: Englisch)
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive...
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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.
Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.
This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.
Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.
This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.
- Outlines the chemical features of PNH
- Explains the mechanism of hemolysis
- Includes work on the biochemistry of glycophosphoinositol anchors
- Contains descriptions of the chemistry and biophysics of GPI-anchored proteins
Bibliographische Angaben
- 2000, 279 Seiten, Englisch
- Herausgegeben: Neal S. Young, Joel Moss
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0080492096
- ISBN-13: 9780080492094
- Erscheinungsdatum: 28.04.2000
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- Größe: 3.87 MB
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Englisch
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