Protein Aggregation in Bacteria / Wiley Series in Protein and Peptide Science (PDF)

Focuses on the aggregation of recombinant proteins in
bacterial cells in the form of inclusion bodies--and on their
use in biotechnological and medical applications

The first book devoted specifically to the topic of aggregation
in bacteria, Protein Aggregation in Bacteria: Functional and
Structural Properties of Inclusion Bodies in Bacterial Cells
provides a large overview of protein folding and aggregation,
including cell biology and methodological aspects. It summarizes,
for the first time in one book, ideas and technical approaches that
pave the way for a direct use of inclusion bodies in
biotechnological and medical applications.

Protein Aggregation in Bacteria covers:

* Molecular and cellular mechanisms of protein folding,
aggregation, and disaggregation in bacteria

* Physiological importance and consequences of aggregation for
the bacterial cell

* Factors inherent to the protein sequence responsible for
aggregation and evolutionary mechanisms to keep proteins
soluble

* Structural properties of proteins expressed as soluble
aggregates and as inclusion bodies within bacterial cells both from
a methodological point of view and with regard to their similarity
with amyloids

* Control of the structural and functional properties of
aggregated proteins and use thereof in biotechnology and
medicine

Protein Aggregation in Bacteria is ideal for researchers
in protein science, biochemistry, bioengineering, biophysics,
microbiology, medicine, and biotechnology, particularly if they are
related with the production of recombinant proteins and
pharmaceutical science.