Protein Degradation (PDF)
Vol. 2: The Ubiquitin-Proteasome System
(Sprache: Englisch)
The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.
Drawing on the combined knowledge of the world's leading protein...
Drawing on the combined knowledge of the world's leading protein...
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The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.
Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation.
Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation.
Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Inhaltsverzeichnis zu „Protein Degradation (PDF)“
Degrons: signals and sites for ubiquitylation The proteasome portal and regulation of proteolysis PAN and the proteasome Ubiquitin domain proteins MEKK1: dual function as a protein kinase and a ubiquitin protein ligase HECT domain ubiquitin protein ligases UCRP: ubiquitin cross-reactive protein SUMOs and their function in the cell Functions of the ubiquitin-proteasome pathway Molecular Chaperones and the ubiquitin/proteasome system Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes Electron microscopy of compartmentalised proteases Molecular dissection of autophagy in yeast
Autoren-Porträt
John Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.
Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.
Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.
Bibliographische Angaben
- 2008, 1. Auflage, 286 Seiten, Englisch
- Herausgegeben: R. John Mayer, Aaron J. Ciechanover, Martin Rechsteiner
- Verlag: Wiley-VCH GmbH
- ISBN-10: 3527620362
- ISBN-13: 9783527620364
- Erscheinungsdatum: 25.06.2008
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