Protein Surface Recognition (PDF)

A new perspective on the design of molecular therapeutics is
emerging. This new strategy emphasizes the rational complementation
of functionality along extended patches of a protein surface with
the aim of inhibiting protein/protein interactions. The successful
development of compounds able to inhibit these interactions offers
a unique chance to selectively intervene in a large number of key
cellular processes related to human disease.

Protein Surface Recognition presents a detailed treatment
of this strategy, with topics including:

* an extended survey of protein-protein interactions that are key
players in human disease and biology and the potential for
therapeutics derived from this new perspective

* the fundamental physical issues that surround protein-protein
interactions that must be considered when designing ligands for
protein surfaces

* examples of protein surface-small molecule interactions,
including treatments of protein-natural product interactions,
protein-interface peptides, and rational approaches to protein
surface recognition from model to biological systems

* a survey of techniques that will be integral to the discovery
of new small molecule protein surface binders, from high throughput
synthesis and screening techniques to in silico and in
vitro methods for the discovery of novel protein ligands.

Protein Surface Recognition provides an intellectual
"tool-kit" for investigators in medicinal and
bioorganic chemistry looking to exploit this emerging paradigm in
drug discovery.