Pyrrole-Imidazole Alkaloids from Marine Sponges: Structural Variation and Cytotoxicity of (–)-Dibromophakellstatin, Synthesis of Ugibohlin and Oroidin, and Studies Towards Oxocyclostylidol (PDF)
(Sprache: Englisch)
Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an...
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Oroidin is considered to be the biogenetic key metabolite of the pyrroleimidazole alkaloids. Several syntheses are known to date, all of which contain steps with only moderate yields. For a study on its reactivity large quantities are needed. Therefore, an improved synthesis would be beneficial. In the present work two different known routes to 8 were investigated. By following the method developed in our group (via Sonogashira coupling) several analogues arose as new products. By treating the two deaminated analogs 1 and 4 with NBS in TFA, no cyclization to the phakellin skeleton 3 took place. Instead, pyrrole oxidation occurred (Scheme 1).
Bibliographische Angaben
- 2012, 176 Seiten, Englisch
- Verlag: Cuvillier Verlag
- ISBN-10: 3736942281
- ISBN-13: 9783736942288
- Erscheinungsdatum: 11.09.2012
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- Größe: 2.52 MB
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Englisch
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