Selection Bias and Covariate Imbalances in Randomized Clinical Trials (PDF)
(Sprache: Englisch)
Selection bias can, and does, occur, even in randomized clinical
trials. Steps need to be taken in order to ensure that this does
not compromise the integrity of clinical trials; hence
"Selection Bias and Covariate Imbalances in Randomized
Clinical...
trials. Steps need to be taken in order to ensure that this does
not compromise the integrity of clinical trials; hence
"Selection Bias and Covariate Imbalances in Randomized
Clinical...
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Selection bias can, and does, occur, even in randomized clinical
trials. Steps need to be taken in order to ensure that this does
not compromise the integrity of clinical trials; hence
"Selection Bias and Covariate Imbalances in Randomized
Clinical Trials" offers a comprehensive treatment of the
subject and the methodology involved. This book:
* Provides an overview of the hierarchy of study designs, and
justifies the position of randomised trials at the top of this
hierarchy.
* Discusses the strengths and defects of randomisation, and
provides real evidence to justify concern regarding its
defects.
* Outlays the damaging consequences that selection bias causes
when it does occur.
* Considers courses of action that can be taken to manage/
contain the problem.
* Presents methods that can be used to detect selection bias in
randomised trials, and methods to correct for selection bias.
* Concludes by providing a comprehensive plan for managing
baseline imbalances and selection bias in randomised trials, and
proposing open problems for future research.
Illustrated with case studies, this book introduces
groundbreaking ideas and research that will be invaluable to
researchers and practitioners who design and analyse clinical
trials. It will also be of interest to graduate students within the
field of biostatistics.
trials. Steps need to be taken in order to ensure that this does
not compromise the integrity of clinical trials; hence
"Selection Bias and Covariate Imbalances in Randomized
Clinical Trials" offers a comprehensive treatment of the
subject and the methodology involved. This book:
* Provides an overview of the hierarchy of study designs, and
justifies the position of randomised trials at the top of this
hierarchy.
* Discusses the strengths and defects of randomisation, and
provides real evidence to justify concern regarding its
defects.
* Outlays the damaging consequences that selection bias causes
when it does occur.
* Considers courses of action that can be taken to manage/
contain the problem.
* Presents methods that can be used to detect selection bias in
randomised trials, and methods to correct for selection bias.
* Concludes by providing a comprehensive plan for managing
baseline imbalances and selection bias in randomised trials, and
proposing open problems for future research.
Illustrated with case studies, this book introduces
groundbreaking ideas and research that will be invaluable to
researchers and practitioners who design and analyse clinical
trials. It will also be of interest to graduate students within the
field of biostatistics.
Autoren-Porträt von Vance Berger
Vance Berger is the author of Selection Bias and Covariate Imbalances in Randomized Clinical Trials, published by Wiley.
Bibliographische Angaben
- Autor: Vance Berger
- 2007, 1. Auflage, 218 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 0470863633
- ISBN-13: 9780470863633
- Erscheinungsdatum: 22.10.2007
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