Single-Molecule Biophysics / Advances in Chemical Physics Bd.146 (ePub)

Preface xiii Part One Developments on Single-Molecule Experiments Staring at a Protein: Ensemble and Single-Molecule Investigations on Protein-Folding Dynamics 3 By Satoshi Takahashi and Kiyoto Kamagata Single-Molecule FRET of Protein-Folding Dynamics 23 By Daniel Nettels and Benjamin Schuler Quantitative Analysis of Single-Molecule FRET Signals and its Application to Telomere DNA 49 By Kenji Okamoto and Masahide Terazima Force to Unbind Ligand-Receptor Complexes and the Internal Rigidity of Globular Proteins Probed by Single-Molecule Force Spectroscopy 71 By Atsushi Ikai, Rehana Afrin, and Hiroshi Sekiguchi Recent Advances in Single-Molecule Biophysics with the Use of Atomic Force Microscopy 89 By Masaru Kawakami and Yukinori Taniguchi Dynamical Single-Molecule Observations of Membrane Protein Using High-Energy Probes 133 By Yuji C. Sasaki Single-Molecular Gating Dynamics for the KcsA Potassium Channel 147 By Shigetoshi Oiki, Hirofumi Shimizu, Masayuki Iwamoto, and Takashi Konno Static and Dynamic Disorder in IN VITRO Reconstituted Receptor-Adaptor Interaction 195 By Hiroaki Takagi, Miki Morimatsu, and Yasushi Sako Part Two Developments on Single-Molecule Theories and Analyses Change-Point Localization and Wavelet Spectral Analysis of Single-Molecule Time Series 219 By Haw Yang Theory of Single-Molecule FRET Efficiency Histograms 245 By Irina V. Gopich and Attila Szabo Multidimensional Energy Landscapes in Single-Molecule Biophysics 299 By Akinori Baba and Tamiki Komatsuzaki Generalized Michaelis-Menten Equation for Conformation Modulated Monomeric Enzymes 329 By Jianlan Wu and Jianshu Cao Making it Possible: Constructing a Reliable Mechanism from a Finite Trajectory 367 By Ophir Flomenbom Free Energy Landscapes of Proteins: Insights from Mechanical Probes 395 By Zu Thur Yew, Peter D. Olmsted, and Emanuele Paci Mechanochemical Coupling Revealed by the Fluctuation Analysis of Different Biomolecular Motors 419 By Hiroaki Takagi and Masatoshi Nishikawa Author Index

Volume Editors

Tamiki Komatsuzaki is a Professor in the Molecule and Life
Nonlinear Sciences Laboratory, Research Institute for Electronic
Science at Hokkaido University in Japan. His research interests
include origin of selectivity and stochasticity of reactions,
single-molecule biophysics, as well as protein landscape and
complexity in kinetics and dynamics.

Masaru Kawakami is an Associate Professor at the Japan
Advanced Institute of Science and Technology (JAIST) School of
Material Science. He specializes in biophysics, single-molecule
measurement, protein folding, and structural biology, and his
research focuses on single-molecule dynamics of biomolecules.

Satoshi Takahashi is a Professor at the Institute of
Multidisciplinary Research for Advanced Materials, Tohoku
University, Japan. His research focuses on protein folding and
functional dynamics.

Haw Yang is an Associate Professor in the Department of
Chemistry at Princeton University. His current research focuses on
high-resolution quantitative single-molecule protein dynamics and
real-time 3D single-particle tracking spectroscopy.

Robert J. Silbey is the Class of 1942 Professor of
Chemistry at MIT. His research involves theoretical studies of
single-molecule spectroscopy at low temperatures, energy and
electron transfer and relaxation in molecular aggregates, the
optical and electronic properties of conjugated oligomers and
polymers, and the transport of charge in organic systems.

Series Editors

Stuart A. Rice received his master's and doctorate from Harvard
University and was a junior fellow at Harvard for two years before
joining the faculty of the University of Chicago in 1957, where he
is currently the Frank P. Hixon Distinguished Service Professor
Emeritus.

Aaron R. Dinner received his bachelor's degree and
doctorate from Harvard University, after which he conducted
postdoctoral research at the University of Oxford and the
University of California,

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