Sox2 (ePub)
Sox2: Biology and Role in Development and Disease offers a thorough discussion of the important role of Sox2 in cellular and developmental processes, aimed at facilitating greater understanding of how Sox2 functions across different disciplines....
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Sox2: Biology and Role in Development and Disease offers a thorough discussion of the important role of Sox2 in cellular and developmental processes, aimed at facilitating greater understanding of how Sox2 functions across different disciplines. The book discusses the basic biology of Sox2 to help establish the critical foundational knowledge necessary for deeper molecular and functional analysis. The book also provides insight into how the Sox2 transcription factor plays a key role in pluripotency induction, maintenance, and development.
Helpful as a tool to organize new research projects, the book assists with preparing lessons, seminars, and thesis or research papers, thereby circumventing the need to spend hours searching through journal databases. A single source for the basic biology of Sox2, Sox2: Biology and Its Role in Development and Disease provides information on networks, gene regulation, and regulatory function in a number of cell types and tissues types.
- Discusses the important role of Sox2 in cellular and developmental processes
- Facilitates a greater understanding of how Sox2 functions across different disciplines
- Assists in identifying, circumventing and modifying the dynamics of Sox2 in cell types
- Provides greater understanding of the structure of Sox2 and its gene networks
- Identifies aspects of phenotypic spectrum uncovered following greater understanding of Sox2 during development
Robin Lovell-Badge is a developmental biologist, geneticist and stem cell biologist at NIMR in London. He obtained his PhD in Embryology at University College London in 1978, carrying out mouse stem cell and embryo research with Martin Evans. After postdoctoral research in Cambridge, also with Martin Evans, and then in Paris, he established his independent laboratory in 1982 at the MRC Mammalian Development Unit, University College, London, directed by Anne McLaren. In 1988 he moved to the MRC National Institute for Medical Research (which was incorporated into the Francis Crick Institute in April 2015), becoming Head of Division in 1993. His lab discovered the first members of the Sox gene family, along with Sry, the Y-linked sex determining gene, in 1990. He has had long-standing interests in the biology of stem cells, in how genes work in the context of embryo development, and how decisions of cell fate are made. Major themes of his current work include sex determination, development of the nervous system and pituitary, and the biology of stem cells within the early embryo, the CNS and the
He was elected a member of EMBO in 1993, a Fellow of the Academy of Medical Sciences in 1999, and a fellow of the Royal Society in 2001. He has received the Louis Jeantet Prize for Medicine (1995), the Amory Prize (Awarded by the American Academy of Arts and Sciences) (1996), the Feldberg Foundation Prize (2008), and the Waddington Medal of the British Society for Developmental Biology (2010). He is also an honorary professor at University College, London and a Distinguished Visiting Professor at the University of Hong Kong.
- 2015, 344 Seiten, Englisch
- Herausgegeben: Hisato Kondoh, Robin Lovell-Badge
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0128004207
- ISBN-13: 9780128004203
- Erscheinungsdatum: 24.08.2015
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: ePub
- Größe: 14 MB
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