Strategies for Organic Drug Synthesis and Design (PDF)
(Sprache: Englisch)
This book examines and evaluates the strategies utilized to design
and synthesize pharmaceutically active agents. Significant updates
over the last 10 years since the publication of the 1st edition
include synthesis of enantiomerically pure isomers,...
and synthesize pharmaceutically active agents. Significant updates
over the last 10 years since the publication of the 1st edition
include synthesis of enantiomerically pure isomers,...
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This book examines and evaluates the strategies utilized to design
and synthesize pharmaceutically active agents. Significant updates
over the last 10 years since the publication of the 1st edition
include synthesis of enantiomerically pure isomers, novel chemical
methodologies, and new pharmaceutical agents targeted at novel
biological endpoints. Written by an experienced successful author,
this book meets the needs of a growing community of researchers in
pharmaceutical R &D, as well as medical professionals, by
providing a useful guide for designing and synthesizing
pharmaceutical agents. Additionally, it is a useful text for
medicinal chemistry students.
and synthesize pharmaceutically active agents. Significant updates
over the last 10 years since the publication of the 1st edition
include synthesis of enantiomerically pure isomers, novel chemical
methodologies, and new pharmaceutical agents targeted at novel
biological endpoints. Written by an experienced successful author,
this book meets the needs of a growing community of researchers in
pharmaceutical R &D, as well as medical professionals, by
providing a useful guide for designing and synthesizing
pharmaceutical agents. Additionally, it is a useful text for
medicinal chemistry students.
Inhaltsverzeichnis zu „Strategies for Organic Drug Synthesis and Design (PDF)“
Preface 1. PROSTAGLANDINS, PEPTIDOMIMETIC COMPOUNDS, AND RETINOIDS. 1.1 Prostaglandnis. 1.2 Peptidonimetic Compounds. 1.3 Retinoids. 1.4 A Miscellaneous Drug. References. 2. DRUG BASED ON A SUBSTITUTED BENZENE RING 2.1 Arylethanolamines. 2.2 Aryloxypropanolamines. 2.3 Arylsulfonic Acid Derivatives. 2.4 Arylacetic and Arylpropionic Acids. 3. INDENES, NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS 3.1 Indenes. 3.2 Naphthalenes. 3.3 Partly Reduced Naphthalenes. 3.4 Tricyclic Compounds. References. 4. STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES 4.1 Introduction. 4.2 Steroid Starting Materials. 4.3 Estranes. 4.4 Gonanes, the 19-nor Steroids. 4.5 Androstanes. References. 5. STEROIDS; PART 2: COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL. 5.1 Introduction. 5.2 Progestins. 5.3 Corticosteroids. 5.4 Compounds Derived from Cholesterol. References. 6. NONSTEROIDAL SEX HORMONES AND THEIR ANTAGONISTS 6.1 Introduction. 6.2 Estrogens. References. 7. OPIOID ANAlGESICS 7.1 Introduction 7.2 Drugs Derived from Morphine. 7.3 Compounds Prepared from Thebaine. 7.4 Morphinans. 7.5 Benzomorphans. 7.6 Analgesics Based on Nonfused Piperidines. References. 8. DRUGS BASED ON FIVE-MEMBERED HETEROCYCLES 8.1 Introduction. 8.2 Rings that Contain One Heteroatom. 8.3 Rings that Contain Two Heteroatoms. 8.4 Rings that Contains Three or More Heteroatoms. References. 9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES. 9.1 Rings that Contain One Heteroatom. 9.2 Rings that Contain Two Heteroatoms. 9.3 Rings Containing Three Heteroatoms: The Triazines. References. 10. FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING. 10.1 Compounds that Contain One Heteroatom. 10.2 Compounds that Contain Two Heteroatoms. 10.3 Compounds that Contain Three Heteroatoms. References. 11. SIX-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING 11.1 Compounds that Contain One Heteroatom. 11.2 Compounds that Contain Two Heteroatoms. 11.3 Compounds that Contain Three Heteroatoms. References. 12. SEVEN-MEMBERED
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HETEROCYCLIC FUSED TO BENZENE. 12.1 Compounds with a Single Heterocyclic Atom. 12.2 Compounds with Two Heteroatoms. References. 13. HETEROCYLES FUSED TO TWO AROMATIC RINGS 13.1 Compounds Containing a Single Heteroatom. 13.2 Compounds Containing Two Heteroatoms. 13.3 Pyridine-Based Fused Tricyclic Compounds. References. 14. BETA LACTAM ANTIBIOTICS 14.1 Penicillins. 14.2 Cephalosporins. 14.3 Monobactams. References. 15. HETEROCYCLES FUSED TO OTHER HETEROCYCLIC RINGS. 15.1 Two Fused Five-Membered Rings. 15.2 Five-Membered Heterocycles Fused to Six-Membered Rings. 15.3 Two Fused Six-Membered Rings. 15.4 Heterodiazepines. 15.5 Heterocyclic Compounds with Three or More Rings. References. Subject Index. Reaction Index. Cross Index of Biological Activities.
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Autoren-Porträt von Daniel Lednicer
Daniel Lednicer, PhD, is the acclaimed author of several books on drug synthesis and discovery. His career has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. He has also served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.
Bibliographische Angaben
- Autor: Daniel Lednicer
- 2009, 2. Auflage, 700 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 0470399597
- ISBN-13: 9780470399590
- Erscheinungsdatum: 26.03.2009
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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