The hERG Cardiac Potassium Channel (PDF)
Structure, Function and Long QT Syndrome
(Sprache: Englisch)
This book draws together contributions from basic, pharmaceutical
and clinical sciences aimed at a better understanding of the
structure and function of hERG and the molecular basis for compound
binding.
It features regulatory authority perspectives...
and clinical sciences aimed at a better understanding of the
structure and function of hERG and the molecular basis for compound
binding.
It features regulatory authority perspectives...
sofort als Download lieferbar
eBook (pdf)
149.99 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „The hERG Cardiac Potassium Channel (PDF)“
This book draws together contributions from basic, pharmaceutical
and clinical sciences aimed at a better understanding of the
structure and function of hERG and the molecular basis for compound
binding.
It features regulatory authority perspectives on preferred
preclinical test systems and includes topics on hERG channel
gating, regulation of functional expression, pharmacological
properties of hERG/IKr channels, drug-induced long QT syndrome and
preclinical evaluation and regulatory recommendations for assessing
QT prolongation risks.
Better understanding of the role of the hERG channel in
drug-induced cardiac arrhythmias should ultimately lead to the
development of important, new and safer medicines.
and clinical sciences aimed at a better understanding of the
structure and function of hERG and the molecular basis for compound
binding.
It features regulatory authority perspectives on preferred
preclinical test systems and includes topics on hERG channel
gating, regulation of functional expression, pharmacological
properties of hERG/IKr channels, drug-induced long QT syndrome and
preclinical evaluation and regulatory recommendations for assessing
QT prolongation risks.
Better understanding of the role of the hERG channel in
drug-induced cardiac arrhythmias should ultimately lead to the
development of important, new and safer medicines.
Inhaltsverzeichnis zu „The hERG Cardiac Potassium Channel (PDF)“
Chair's introduction (Michael Sanguinetti). Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart (Gail A. Robertson, Eugenia M. C. Jones and Jinling Wang). Structure-function studies of outer mouth and voltage sensor domain of hERG (Gea-Ny Tseng and H. Robert Guy). General Discussion I. Voltage sensor movement in the hERG K¯+ channel (David R. Piper,Michael C. Sanguinetti and Martin Tristani-Firouzi). hERG channel trafficking (Eckhard Ficker, Adrienne Dennis,Yuri Kuryshev, Barbara A.Wible and Arthur M. Brown). Dynamic control of hERG/IKrr by PKA-mediated interactions with 14-3-3 (Anna Kagan and Thomas V. McDonald). General Discussion II. Does hERG coassemble with a ß subunit? Evidence for roles of MinK and MiRP1 (Arun Anantharam and Geoffrey W. Abbott). hERG block, QT liability and sudden cardiac death (Arthur M. Brown). Structural determinants for high affinity block of hERG potassium channels ( John Mitcheson, Matthew Perry, Phillip Stansfeld,Mike Sanguinetti,Harry Witchel and Jules Hancox). General Discussion III. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs (Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya,John Mitcheson and José A. Sanchez-Chapula). In silico - modelling pharmacophores and hERG channel models (Maurizio Recanatini, Andrea Cavalli and MatteoMasetti). The long QT syndrome: a clinical counterpart of HERG mutations (Peter J. Schwartz). Cellular mechanisms of Torsade de Pointes (Steven Poelzing and David S. Rosenbaum). Expression and role of HERG channels in cancer cells (Annarosa Arcangeli). TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability) (Luc M. Hondeghem). Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies (Rashmi R. Shah). Closing remarks (Michael Sanguinetti). Index of contributors. Subject index.
Autoren-Porträt
The Novartis Foundation is an international scientific and educational charity that promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Bibliographische Angaben
- 2005, 1. Auflage, 308 Seiten, Englisch
- Herausgegeben: Derek J. Chadwick, Jamie A. Goode
- Verlag: John Wiley & Sons
- ISBN-10: 0470021411
- ISBN-13: 9780470021415
- Erscheinungsdatum: 14.06.2005
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Größe: 2.98 MB
- Mit Kopierschutz
Sprache:
Englisch
Kopierschutz
Dieses eBook können Sie uneingeschränkt auf allen Geräten der tolino Familie lesen. Zum Lesen auf sonstigen eReadern und am PC benötigen Sie eine Adobe ID.
Kommentar zu "The hERG Cardiac Potassium Channel"
0 Gebrauchte Artikel zu „The hERG Cardiac Potassium Channel“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "The hERG Cardiac Potassium Channel".
Kommentar verfassen