Toxicogenomics (PDF)

Toxicogenomics is the integration of genomics to toxicology. This
technology is a powerful tool for collecting information from a
large number of biological samples simultaneously and thus it is
very useful for large-scale screening of potential toxicants.

Toxicogenomics: A Powerful Tool For Toxicity Assessment
provides up-to-date state-of-the-art information presented by the
recognized experts, and is therefore an authoritative source of
current knowledge in this field of research. The potential link
between toxicology, genetics and human diseases makes this book
very useful to investigators in many and varied disciplines of
science and toxicology. Topics covered include:

* mechanistic toxicogenomics

* analysis and interpretation of toxicogenomic data

* principles of data mining in toxicogenomics

* design issues in toxicogenomics studies

* sources of variability in toxicogenomic assays

* Escherichia coli stress response as a tool for detection
of toxicity

* toxicogenomics as a tool to assess immunotoxicity

* toxicogenomics and ecogenomics for studying endocrine
disruption and basic biology

* use of toxicogenomics as an early predictive tool for
hepatotoxicity

* nutrigenomics: the application of genomic signatures in
nutrition-related research

* application of toxicogenomics in drug discovery

* potential uses of toxicogenomic biomarkers in occupational
health and risk assessment

* usefulness of toxicogenomics in the regulatory environment

* perspectives on toxicogenomics at the US Environmental
Protection Agency

Toxicogenomics: A Powerful Tool For Toxicity Assessment
is an essential resource for research scientists currently
engaged in toxicogenomics, and will also be of interest to
researchers working in toxicology, genetics, medicine,
pharmacology, and food sciences, and to regulators and risk
assessors of drug, food, environmental and agricultural
products.