Toxicokinetics and Risk Assessment (ePub)
(Sprache: Englisch)
Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly...
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Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human health risk assessment, as well as methods for data generation, extrapolation, and inclusion of laboratory results for chemical metabolism and computer-based predictions of biochemical constants to address estimates of variability between experimental animals and humans. This guide also includes recent examples of the use of toxicokinetic information to successfully replace default values for uncertainty factors with data-derived factors in risk assessments developed by the US Environmental Protection Agency.
Autoren-Porträt
John C. Lipscomb is a Toxicologist for the U.S. Environmental Protection Agency (EPA), Office of Research and Development, at the National Center for Environmental Assessment in Cincinnati, Ohio. There, Dr. Lipscomb serves as co-leader of a technical panel for the EPA's Risk Assessment Forum, responsible for drafting guidance on the replacement of default uncertainty factors with data-derived uncertainty factors. Prior to joining the EPA, Dr. Lipscomb was a Captain in the United States Air Force and served as chief of the metabolism section in the toxicology division of Armstrong Laboratory, USAF, Wright-Patterson Air Force Base, Ohio. He serves on the Board of Directors of the American Board of Toxicology and has held and continues to act in leadership positions for specialty groups and regional chapters of the Society of Toxicology and the Society for Risk Analysis. Dr. Lipscomb received the B.S. and M.S. degrees from the University of Central Arkansas, Conway, in 1984 and 1986, respectively, and the Ph.D. degree in interdisciplinary toxicology from the University of Arkansas for Medical Sciences, Little Rock, in 1991. He became a Diplomate of the American Board of Toxicology in 1995., Edward V. Ohanian is the Director of the Health and Ecological Criteria Division, Office of Science and Technology, Office of Water at the U.S. Environmental Protection Agency (EPA) in Washington, D.C. He serves as Chairman of the EPA's Risk Assessment Forum, Chairman of the Health Advisory Board for the not-for-profit organization NSF International in Ann Arbor, Michigan, and Co-chairman of the EPA Federal-State Toxicology and Risk Analysis Committee. He is Adjunct Associate Professor of Medicine and Health Care Sciences at the School of Medicine and Health Sciences and the School of Public Health and Health Services, The George Washington University, Washington, D.C., as well as Adjunct Associate Professor of Environmental Health Sciences at the Tulane University Medical Center's
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School of Public Health and Tropical Medicine in New Orleans, Louisiana. Dr. Ohanian received the B.S. degree in biological sciences from Columbia University, New York, New York in 1969, the M.S. degree in physiology from New York Medical College, Valhalla in 1974, and the Ph.D. degree in biomedical sciences from the Mount Sinai School of Medicine, New York, New York in 1976.
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Bibliographische Angaben
- 2016, 361 Seiten, Englisch
- Herausgegeben: John C. Lipscomb, Edward V. Ohanian
- Verlag: Taylor & Francis
- ISBN-10: 1000612139
- ISBN-13: 9781000612134
- Erscheinungsdatum: 19.04.2016
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: ePub
- Größe: 10 MB
- Ohne Kopierschutz
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Sprache:
Englisch
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