Translational Neuroscience (PDF)

Contributors xi Preface xiii Acknowledgments xv 1 A Brief History of Translational Neuroscience 1 Edgar Garcia-Rill Some recent history 1 Funding translational research 3 Lack of funding 4 Making NIH funding more equitable and efficient 6 How much funding is needed? 7 Medical research funding in Europe 10 References 13 2 Mentoring in Translational Neuroscience 15 Edgar Garcia-Rill T1 blocks 15 T2 blocks 20 References 27 3 Core Facilities for Translational Neuroscience 29 Edgar Garcia-Rill Designing translational neuroscience core facilities 31 Preattentional measure--the P50 potential 33 Attentional measures--psychomotor vigilance 35 Frontal lobe blood flow measures 36 References 42 4 Translational Studies Using TMS 43 Mark Mennemeier, Christine Sheffer, Abdallah Hayar, and Roger Buchanan Overview 43 Introduction 44 Development of a sham stimulation technique for humans 45 PET-guided TMS studies of tinnitus perception 46 TMS investigations of decision-making in tobacco addiction 50 TMS investigations in rodents 54 Conclusion 61 References 61 5 Translational Studies in Drug Abuse 67 Veronica Bisagno, William E. Fantegrossi, and Francisco J. Urbano Background and significance 67 Behavioral Core Facility 70 Voltage-sensitive dye imaging 75 Intravenous drug self-administration 75 References 79 6 Electrophysiology in Translational Neuroscience 83 Edgar Garcia-Rill In vivo and in vitro animal models 83 Modafinil 84 Patch clamp recordings 85 Gamma band activity 86 Population responses 88 Preconscious awareness 89 Magnetoencephalography, the Cadillac of human electrophysiology 91 References 94 7 Translational Research on Spinal Cord Injury 97 Charlotte Yates and Kevin Garrison Electrophysiological approach: H-reflex frequency-dependent depression 98 Biomechanical approach: windup of the stretch reflex 100 Interventions: passive exercise 101 Interventions: pharmacology (L-Dopa, Modafinil) 105 Conclusions 106 References 106 8 Translational Research in Neonatology 109 Richard

Edgar Garcia-Rill is Professor of Anatomy and Psychiatry at the University of Arkansas for Medical Sciences. His research interests include sleep disorders, schizophrenia, depression, PTSD, and aches Neuroscience spinal cord injury. Dr. Garcia-Rill is also Director of the Center for Translational Neuroscience, a didivision of division of the Department of Neurobiology & Dev. Sci. and a research arm of the Jackson T. Stephens Spine & Neuroscience Institute, at which novel treatments for the treatment of spinal cord injury are are being developed under the Spinal Cord Injury Mobilization Program.

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