Vascular Development / Novartis Foundation Symposium (PDF)
(Sprache: Englisch)
The formation of blood vessels is an essential aspect of
embryogenesis in vertebrates. It is a central feature of
numerous post-embryonic processes, including tissue and organ
growth and regeneration. It is also part of the pathology of
tumour formation...
embryogenesis in vertebrates. It is a central feature of
numerous post-embryonic processes, including tissue and organ
growth and regeneration. It is also part of the pathology of
tumour formation...
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The formation of blood vessels is an essential aspect of
embryogenesis in vertebrates. It is a central feature of
numerous post-embryonic processes, including tissue and organ
growth and regeneration. It is also part of the pathology of
tumour formation and certain inflammatory conditions.
In recent years, comprehension of the molecular genetics of
blood vessel formation has progressed enormously and studies in
vertebrate model systems, especially the mouse and the zebrafish,
have identified a common set of molecules and processes that are
conserved throughout vertebrate embryogenesis while, in addition,
highlighting aspects that may differ between different animal
groups.
The discovery in the past decade of the crucial role of new
blood vessel formation for the development of cancers has generated
great interest in angiogenesis (the formation of new blood vessels
from pre-existing ones), with its major implications for potential
cancer-control strategies. In addition, there are numerous
situations where therapeutic treatments either require or would be
assisted by vasculogenesis (the de novo formation of blood
vessels). In particular, post-stroke therapies could include
treatments that stimulate neovascularization of the affected
tissues.
The development of such treatments, however, requires thoroughly
understanding the developmental properties of endothelial cells and
the basic biology of blood vessel formation.
While there are many books on angiogenesis, this unique book
focuses on exactly this basic biology and explores blood vessel
formation in connection with tissue development in a range of
animal models. It includes detailed discussions of relevant cell
biology, genetics and embryogenesis of blood vessel formation and
presents insights into the cross-talk between developing blood
vessels and other tissues.
With contributions from vascular biologists, cell biologists and
developmental biologists, a comprehensive and highly
interdisciplinary volume is the outcome.
embryogenesis in vertebrates. It is a central feature of
numerous post-embryonic processes, including tissue and organ
growth and regeneration. It is also part of the pathology of
tumour formation and certain inflammatory conditions.
In recent years, comprehension of the molecular genetics of
blood vessel formation has progressed enormously and studies in
vertebrate model systems, especially the mouse and the zebrafish,
have identified a common set of molecules and processes that are
conserved throughout vertebrate embryogenesis while, in addition,
highlighting aspects that may differ between different animal
groups.
The discovery in the past decade of the crucial role of new
blood vessel formation for the development of cancers has generated
great interest in angiogenesis (the formation of new blood vessels
from pre-existing ones), with its major implications for potential
cancer-control strategies. In addition, there are numerous
situations where therapeutic treatments either require or would be
assisted by vasculogenesis (the de novo formation of blood
vessels). In particular, post-stroke therapies could include
treatments that stimulate neovascularization of the affected
tissues.
The development of such treatments, however, requires thoroughly
understanding the developmental properties of endothelial cells and
the basic biology of blood vessel formation.
While there are many books on angiogenesis, this unique book
focuses on exactly this basic biology and explores blood vessel
formation in connection with tissue development in a range of
animal models. It includes detailed discussions of relevant cell
biology, genetics and embryogenesis of blood vessel formation and
presents insights into the cross-talk between developing blood
vessels and other tissues.
With contributions from vascular biologists, cell biologists and
developmental biologists, a comprehensive and highly
interdisciplinary volume is the outcome.
Inhaltsverzeichnis zu „Vascular Development / Novartis Foundation Symposium (PDF)“
Chair's introduction (Christer Betsholtz). The control of endothelial cell functions by adherens junctions (Maria Grazia Lampugnani and Elisabetta Dejana). Discussion. The role of Egfl 7 in vascular morphogenesis (Maike Schmidt, Ann De Mazière, Tanya Smyczek, Alane Gray, Leon Parker, Ellen Filvaroff, Dorothy French, Suzanne van Dijk, Judith Klumperman and Weilan Ye). Discussion. A model of intussusceptive angiogenesis (Max Levin, Andrew J. Ewald, Martin McMahon, Zena Werb and Keith Mostov). Discussion. Vascular lumen formation from a cell biological perspective (Tomas Kucera, Jan Eglinger, Boris Strilic and Eckhard Lammert). Discussion. The genetics of vasculogenesis (Christopher J. Drake, Paul A. Fleming and W. Scott Argraves). Discussion. Negative regulators of vessel patterning (Anne Eichmann). Discussion. Lymphangiogenesis in development and disease (Taija Mäkinen and Kari Alitalo). Discussion. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis (Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston). Discussion. HIF in vascular development and tumour angiogenesis (Georg Breier, Alexander H. Licht, Anne Klotzsche, Ben Wielockx and Zuzana Kirsnerova). Discussion. Imaging the developing lymphatic system using the zebrafish (Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi and Brant M. Weinstein). Discussion. Signalling pathways regulating cardiac neural crest migration and differentiation (Frances High and Jonathan A. Epstein). Discussion. Investigation of the angiogenic programme with tissue-specifi c and inducible genetic approaches in mice (Ralf H. Adams). Discussion. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity (Gary K. Owens). Discussion. Growth factor gradients in vascular patterning (Andrea Lundkvist, Sunyoung Lee, Patrik
... mehr
Andersson, Fredrik Wolfhagen, Nico Van Rooijen, Peter Carmeliet, Luisa Iruela-Arispe, Christer Betsholtz and Holger Gerhardt). Discussion. Endothelial cell promotion of early liver and pancreas development (Deborah A. Freedman, Yasushige Kashima and Kenneth S. Zaret). Discussion. Embryonic development and malformation of lymphatic vessels (Jörg Wilting, Kerstin Buttler, Jochen Rössler, Susanne Norgall, Lothar Schweigerer, Herbert A. Weich and Maria Papoutsi). Discussion. Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse (Joaquim Miguel Vieira, Quenten Schwarz and Christiana Ruhrberg). Discussion. Final discussion. Tracheal tube development in Drosophila. Closing remarks. Index of contributors. Subject index.
... weniger
Autoren-Porträt
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
Bibliographische Angaben
- 2007, 1. Auflage, 260 Seiten, Englisch
- Herausgegeben: Derek J. Chadwick, Jamie A. Goode
- Verlag: John Wiley & Sons
- ISBN-10: 0470319429
- ISBN-13: 9780470319420
- Erscheinungsdatum: 20.08.2007
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