Viral Fitness and Evolution / Current Topics in Microbiology and Immunology Bd.439 (PDF)

developed a theory of evolution merging chemical reaction kinetics with molecular biology and leading to new concepts such as molecular quasispecies and catalytic hypercycles. He conceived a new theory of phenotype evolution on landscapes and applied it to RNA populations in test-tube experiments and viral communities.

Santiago Elena is CSIC professor and co-chairman of the Institute for Integrative Systems Biology (I2SysBio), where he is the head of the Evolutionary and Systems Virology group. In addition, he is an external professor at the Santa Fe Institute (NM, USA). He graduated in Biochemistry and did a PhD thesis on Evolutionary Genetics of RNA viruses at the University of Valencia. His work has always focused on the study of the mechanisms by which RNA viruses adapt to their hosts and how this adaptation results in the manipulation of cellular resources for their own benefit. For this work, he combines experimental evolution, molecular biology and omics, molecular epidemiology, and mathematical modeling. Among other merits, he is an elected member of the European Organization for Molecular Biology (EMBO), the Chinese Academy of Agronomic Sciences (CAAS), and the American Academy of Arts and Sciences (AAA&S).

Celia Perales is Staff Scientist at the Centro Nacional de Biotecnología (CNB-CSIC) and associated researcher at the Fundación Jiménez Díaz in Madrid. She graduated in Chemistry, specialized in Molecular Biology and Biochemistry and did her PhD thesis studying several aspects of the human immunodeficiency virus translation. She has worked during the last 15 years on evolution of RNA viruses and on the molecular mechanisms involved in virus extinction through antiviral treatments including lethal mutagenesis. Her expertise in molecular and clinical virology and the application of ultra-deep sequencing analysis has contributed to the understanding of viral dynamics and the response to inhibitors of hepatitis C virus both in cell culture and in clinical settings, and now applied to other RNA viruses. She is a Member of the Spanish Society of Biochemistry and Molecular Biology, the Spanish Society of Virology, and the Center for Biomedical Research Network on Liver and Digestive Diseases.