ABC Transporters and Multidrug Resistance / Wiley series in drug discovery and development (PDF)
(Sprache: Englisch)
A comprehensive review of the most current scientific research
on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are
known to play a crucial role in the development of multidrug
resistance (MDR)....
on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are
known to play a crucial role in the development of multidrug
resistance (MDR)....
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A comprehensive review of the most current scientific research
on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are
known to play a crucial role in the development of multidrug
resistance (MDR). MDR is the ability of pathologic cells, such as
tumors, to withstand chemicals designed to target and destroy such
cells. In MDR, patients who are on medication eventually develop
resistance to not only the drug they are taking, but to several
different types of drugs.
ABC Transporters and Multidrug Resistance offers an
essential resource for pharmaceutical researchers who are working
to discover drugs to counteract multidrug resistance in diseases
such as cancer. In one comprehensive volume, this book contains a
collection of the most current knowledge on the involvement of ABC
transporters in drug transport and resistance.
This comprehensive volume provides an overview on the
description of the structure, the genome, normal tissue expression,
physiological aspect, and mechanism of action of the ABC protein.
The expert contributors explore the expression, detection, and
implications of ABC proteins in hematological malignancies and
solid tumors and ABC proteins and pathogenic microorganisms. This
volume also explains MDR modulation through inhibition of ABC
transporters and the design of inhibitors and mechanism of action.
In addition, the book offers essential information on the
biological and clinical aspect of multidrug resistance.
on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are
known to play a crucial role in the development of multidrug
resistance (MDR). MDR is the ability of pathologic cells, such as
tumors, to withstand chemicals designed to target and destroy such
cells. In MDR, patients who are on medication eventually develop
resistance to not only the drug they are taking, but to several
different types of drugs.
ABC Transporters and Multidrug Resistance offers an
essential resource for pharmaceutical researchers who are working
to discover drugs to counteract multidrug resistance in diseases
such as cancer. In one comprehensive volume, this book contains a
collection of the most current knowledge on the involvement of ABC
transporters in drug transport and resistance.
This comprehensive volume provides an overview on the
description of the structure, the genome, normal tissue expression,
physiological aspect, and mechanism of action of the ABC protein.
The expert contributors explore the expression, detection, and
implications of ABC proteins in hematological malignancies and
solid tumors and ABC proteins and pathogenic microorganisms. This
volume also explains MDR modulation through inhibition of ABC
transporters and the design of inhibitors and mechanism of action.
In addition, the book offers essential information on the
biological and clinical aspect of multidrug resistance.
Inhaltsverzeichnis zu „ABC Transporters and Multidrug Resistance / Wiley series in drug discovery and development (PDF)“
PREFACE. CONTRIBUTORS. INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE (Jonathan A. Sheps and Victor Ling). PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION. 1 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule (Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier, and Marie-Hélène Ratinaud). 2 Multidrug resistance-associated protein (MRP/ABCC proteins) (Mylène Honorat, Charles Dumontet, and Lea Payen). 3 ABCG2: A new challenge in cancer drug resistance (Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch, and Susan E. Bates). PART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS. 4 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia (Ollivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie). 5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors (Jean François Bernaudin, Anne Fajac, Jocelyne Fleury-Feith, Khaldoun Kerrou, and Roger Lacave). PART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS. 6 ABC transporters and resistance to antibiotics (Serge Michalet and Marie-Geneviève Dijoux-Franca). 7 ABC proteins involved in protozoan parasite resistance (Bruno Pradines). PART IV MULTIDRUG RESISTANCE (MDR) MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS: DESIGN OF INHIBITORS AND MECHANISM OF ACTION. 8 Reversal agents for P-glycoprotein-mediated multidrug resistance (Hamid Morjani and Claudie Madoulet). 9 Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs) (Ahcène Boumendjel, Anne Florin, and Jean Boutonnat). 10 Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance (Jean Boutonnat, Anne Florin, and Ahcène Boumendjel). 11 Strategies to overcome drug
... mehr
resistance in acute and chronic leukemias (Eric Solary, Vincent Ribrag, and Stéphane de Botton). 12 Multidrug resistance reversal in solid tumors (Tatiana Bogush and Jacques Robert). PART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE: THE ROLE OF THE TRANSPORTERS AT THE MAIN PROTECTION BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE BIOAVAILABILITY OF MANY TYPES OF DRUGS AND MEDICATIONS. 13 ABC superfamily transporters at the human blood-brain barrier (Jean-Michel Scherrmann). 14 The role of ABC transporters at the intestinal barrier (Roos L. Oostendorp, Jos H. Beijnen, and Jan H.M. Schellens). 15 Genetic polymorphisms in ABC transporters (Leslie W. Chinn and Deanna L. Kroetz). PERSPECTIVES. INDEX.
... weniger
Autoren-Porträt
Ahcéne Boumendjel is Professor of Medicinal Chemistryat the University of Grenoble School of Pharmacy, France.
Jean Boutonnat is an Assistant Professor and Hospital
Practitioner at the Grenoble Medical School and Université
Joseph Fourier of Grenoble, France.
Jacques Robert is Professor and Head of the Laboratory of
Pharmacology of Anticancer Agents at Institut Bergonié and
Université Victor Segalen Bordeaux 2, France.
Bibliographische Angaben
- 2009, 1. Auflage, 480 Seiten, Englisch
- Herausgegeben: Ahcène Boumendjel, Jean Boutonnat, Jacques Robert
- Verlag: John Wiley & Sons
- ISBN-10: 047049512X
- ISBN-13: 9780470495124
- Erscheinungsdatum: 18.06.2009
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