Evaluation of Drug Candidates for Preclinical Development / Wiley series in drug discovery and development (PDF)

Emphasizes the integration of major areas of drug discovery and
their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for
development is the key to success. In the last decade,
pharmaceutical R&D departments have integrated pharmacokinetics
and drug metabolism, pharmaceutics, and toxicology into early drug
discovery to improve the assessment of potential drug compounds.
Now, Evaluation of Drug Candidates for Preclinical Development
provides a complete view and understanding of why
absorption-distribution-metabolism-excretion-toxicology (ADMET)
plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which
optimization and evaluation of drug developability is most
critical--pharmacokinetics and drug metabolism, pharmaceutics,
and safety assessment--this unique resource encourages
integrated thinking in drug discovery. The contributors to this
volume:

* Cover drug transporters, cytochrome P-450 and drug-drug
interactions, plasma protein binding, stability, drug formulation,
preclinical safety assessment, toxicology, and toxicokinetics

* Address developability issues that challenge pharma companies,
moving beyond isolated experimental results

* Reveal connections between the key scientific areas that are
critical for successful drug discovery and development

* Inspire forward-thinking strategies and decision-making
processes in preclinical evaluation to maximize the potential of
drug candidates to progress through development efficiently and
meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves
as an introductory reference for those new to the pharmaceutical
industry and drug discovery in particular. It is especially well
suited for scientists and management teams in small- to mid-sized
pharmaceutical companies, as well as academic researchers and
graduate students concerned with the practical aspects related to
the evaluation of drug developability.