Carbohydrates in Drug Discovery and Development
Synthesis and Application
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of...
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Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these propertiesfor the past several decades.This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more.
Bibliographische Angaben
- Herausgegeben:Tiwari, Vinod K.
- Verlag: Elsevier Science & Technology
- EAN: 9780128166758
Autoren-Porträt
Vinod K. Tiwari is an Associate Professor of Organic Chemistry at Banaras Hindu University, India. Dr. Tiwari has taught almost all branches of organic chemistry for the last 16 years. His current research focuses on synthetic carbohydrate chemistry. Dr. Tiwari has supervised twelve PhD theses and his research has been documented in 140 peer-reviewed publications. Additionally, Dr. Tiwari holds several patents & has written book chapters which have received awards from various academic societies. He is a highly-travelled scientist and has delivered over 155 invited lectures in India and abroad. Currently, Dr. Tiwari holds the position of Secretary for the Association of Carbohydrate Chemist and Technologists in India.
Inhaltsverzeichnis zu „Carbohydrates in Drug Discovery and Development “
1. Recent trends and challenges on carbohydrate-based molecular scaffolding: general consideration toward impact of carbohydrates in drug discovery and development2. Heparin mimetics as tools for modulation of biology and therapy
3. Bioactive C-glycosides inspired from natural products toward therapeutics
4. 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) derivatives in antibacterial drug discovery
5. Sialic acid-containing molecules in drug discovery and development
6. Glycan microarray: Toward drug discovery and development
7. Recent developments in the synthesis of biologically relevant Iinositol derivatives
8. Iminosugars in medicinal chemistry
9. Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding
10. Carbo-click in drug discovery and development: Opportunity and challenges
11. Glycohybrids molecule in medicinal chemistry: Present status and future prospective
12. Biologically active carbohydrate-containing macrocycles
13. Carbohydrate-based antibiotics: Opportunities and challenges
14. Carbohydrate-based anti-bacterial and anti-cancer vaccines
15. Opportunity of plant oligosaccharides and polysaccharides in drug development
16. N-acetylgalactosamine (GalNAc)-conjugates: Delivering oligonucleotide drugs to the liver
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