Neurotoxicity of Pesticides
Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of...
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Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others.
Bibliographische Angaben
- Herausgegeben:Aschner, Michael; Costa, Lucio G.
- Verlag: Academic Press
- EAN: 9780128205150
Autoren-Porträt
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg's neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.
Inhaltsverzeichnis zu „Neurotoxicity of Pesticides “
1. Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN) Rudy J. Richardson, John K. Fink, Paul Glynn, Robert B. Hufnagel, Galina F. Makhaeva and Sanjeeva J. Wijeyesakere 2. Neurotoxicity of organophosphate nerve agents Ramesh C. Gupta 3. Neurotoxicology of pyrethroid insecticides David M. Soderlund 4. Neurotoxicity of Neonicotinoids Arturo Anadón, Irma Ares, Marta Martínez, María Rosa Martínez-Larrañaga and María Aránzazu Martínez 5. Rotenone neurotoxicity: Relevance to Parkinson's disease Vivek Lawana and Jason R Cannon 6. Neurotoxicity of amitraz, a formamidine pesticide Lucio G. Costa
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