New Therapeutic Strategies for Brain Edema and Cell Injury

Aruna Sharma, MD is currently Secretary of Research at Uppsala University Hospital, Uppsala University, Sweden. She obtained her Bachelor of Science in 1971 and trained in Indian Medicine up to 1977 and engaged in medical research from 1978 to 1986 in India on hyperthermia induced brain dysfunction in the lab of Hari Sharma and Prasanta Kumar Dey under University Grants Commission and Indian Council of Medical Research

Her main interest is now focused on Indian Medicinal drugs and their effects on the Central Nervous System Function, toxicology, neurorepair and neuroprotection. She is also investigating neurotoxicological profiles of many Ayurvedic traditional drugs with special reference to those containing metal oxide or metal ashes.

1. 5-hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology Aruna Sharma, Rudy J. Castellani, Mark A. Smith, Dafin F. Muresanu, Prasanta Kumar Dey and Hari S. Sharma 2. Anaesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology, and functional outcome Hari S. Sharma, Dafin F. Muresanu, Ala Nozari, Rudy J. Castellani, Prasanta K. Dey, Lars Wiklund and Aruna Sharma 3. Exacerbation of blood-brain barrier breakdown, edema formation, nitric oxide synthase upregulation, and brain pathology after heat stroke in diabetic and hypertensive rats: Potential neuroprotection with cerebrolysin treatment Dafin F. Muresanu, Aruna Sharma, Ranjana Patnaik, Preeti K. Menon, Herbert Mössler and Hari Shanker Sharma 4. Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140on microvascular permeability, blood flow disturbances, edema formation, cell injury, and nitric oxide synthase upregulation following trauma to the spinal cord Hari Shanker Sharma, Lianyuan Feng, Dafin Fior Muresanu, Rudy J. Castellani and Aruna Sharma 5. Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation Seaab Sahib, Feng Niu, Aruna Sharma, Lianyuan Feng, Z. Ryan Tian, Dafin F. Muresanu, Ala Nozari and Hari Shanker Sharma 6. Leakage of the blood-brain barrier followed by vasogenic edema as the ultimate cause of death induced by acute methamphetamine overdose Eugene A. Kiyatkin and Hari S. Sharma 7. Neuroprotective effects of 5-HT3 receptor antagonist ondansetron on morphine withdrawal induced brain edema formation, blood-brain barrier dysfunction, neuronal injuries, glial activation, and