Quinones and Quinone Enzymes, Part B

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named 'Redox Pioneer'; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of "Oxidative Stress? in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

Section I: Mitochondrial Ubiquinone and Reductases1: Mitochondrial Quinone Reductases: Complex I2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes3: Targeting Coenzyme Q Derivatives to Mitochondria4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency6: Coenzyme Q Cytoprotective Mechanisms7: Dietary Coenzyme Q10 and Mitochondrial StatusSection II: Anticancer Quinones and Quinone Oxidoreductases8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)10: Diaziridinylbenzoquinones11: Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications12: Bioactivation and Resistance to Mitomycin C13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells14: The "Prochaska? Microtiter Plate Bioassay for Inducers of NQO115: Structure-Activity Relationships in Two-Electron Reduction of Quinones16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 117: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases18: Induction of NQO1 in Cancer CellsSection III: Quinone Reductases: Chemoprevention and Nutrition19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview25: Upregulation of Quinone Reductase by