Regulated Cell Death Part B

Dr Avi Ashkenazi received his PhD in Biochemistry in 1986 from the Hebrew University of Jerusalem, Israel. From 1986 to 1989 he trained as a postdoctoral fellow at the University of California, San Francisco, and the biotechnology company, Genentech. As a postdoc, he helped identify the muscarinic acetylcholine receptor gene family and deciphered its interactions with specific G proteins - work that in 1988 earned him and two of his colleagues the first prize of the Boehringer Ingelheim Award. In 1989 Dr Ashkenazi joined Genentech as s Scientist and progressed through the ranks to become Senior Staff Scientist and Director, most recently within the Research Oncology division. In the early 1990's he contributed to the development and translation of a technology to fuse immunoglobulin Fc domains to other proteins, now used in numerous research laboratories and in important biotechnology drugs including Enbrel® and Eylea®. Subsequently, Dr Ashkenazi's laboratory discovered several novel members of the tumor necrosis factor (TNF) superfamily, most notably, the apoptosis-inducing ligand Apo2L/TRAIL and its "death? and "decoy? receptors. Dr Ashkenazi's basic research has focused on the mechanisms of apoptosis signaling by death receptors, and his translational work in this area pioneered the clinical development of pro-apoptotic receptor agonists (PARAs) for cancer therapy. To date, Dr Ashkenazi has published 110 research papers and 31 review articles and has co-edited a book on antibody fusion proteins. His top 5 publications have been cited in sum over 11,000 times. His work on death receptors is highlighted in the textbook: "The biology of Cancer? by Robert A. Weinberg. He has presented 99 lectures at scientific institutions and conferences and is a named inventor on 59 issued US patents. Dr Ashkenazi co-chaired the international TNF conference in 2007 and has served or serves on the editorial boards of Current Biology, Clinical Cancer Research, Nature Reviews Cancer,

1. Assays for Necroptosis and Activity of RIP Kinases
2. IAP Family of Cell Death and Signaling Regulators
3. Activation of the NLRP3 Inflammasome by Proteins that Signal for Necroptosis
4. Characterization of the Ripoptosome and its Components - Implications for Anti-Inflammatory and Cancer Therapy
5. Tools and Techniques to Study Ligand-Receptor Interactions and Receptor Activation by TNF Superfamily Members
6. Necrotic Cell Death in Caenorhabditis elegans
7. Noncanonical Cell Death in the Nematode Caenorhabditis elegans
8. Autophagy and Cell Death in the Fly
9. Structural Studies of Death Receptors
10. Use of E2~Ubiquitin Conjugates for the Characterization of Ubiquitin Transfer by RING E3 Ligases such as the Inhibitor of Apoptosis Proteins
11. Multidimensional Profiling in the Investigation of Small-Molecule-Induced Cell Death