The Oncogene and Tumour Suppressor Gene Factsbook

The Introductory Chapters:
Introduction: Identification of Oncogenes.
Oncogene Activation in Humans.
Proliferation Control Pathways: Oncoprotein Function.
Growth Factor-Related Proteins.
SRC. RAS and RAF.
Nuclear Oncoproteins.
ETS. FOS and JUN. MYB. MYC. REL. ERBA.
Tumour Suppressor Genes: RB1. P53.
Other Major Tumour Suppressor Genes.
APC. BRCA1. NF1. VHL. WT1.
Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).
Apoptosis: Tumour Suppressor Genes and Apoptosis.
DNA Repair.
Angiogenesis and Metastasis: Angiogenesis.
Angiogenic Promoters.
Angiogenic Inhibitors.
Metastasis: Correlations with Gene Expression.
Cadherins.
The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).
Integrins.
CD44.
Matrix Metalloproteinases (MMPS).
Tissue Inhibitors of Metalloproteinases (TIMPs).
Cysteine and Aspartic Proteinases and Heparanase.
NME1 and NME2.
The Multi-step Nature of Cancer: Cervical Carcinoma.
Colorectal Carcinoma.
Breast Carcinoma.
Prostate Carcinoma.
Renal Cell Carcinoma.
Lung Carcinoma.
Lymphomas.
Chronic Myeloid Leukemia.
Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.
Tumour Suppressor Gene Therapy.
Cytokine Gene Therapy and Tumour Vaccination.
Virally Directed Enzyme Prodrug Therapy (VDEPT).
Antibody-directed Therapy.
Tables:
Oncogenes Transduced by Retroviruses.
Oncogenes Activated by Retroviral Insertion.
Oncogenes at Chromosomal Translocations.
Tumour Suppressor Genes Detected in Human Tumours.
Functions of Oncoproteins.
Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.
The Oncogenes:
ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC.