Abeta Peptide and Alzheimer's Disease
Celebrating a Century of Research
(Sprache: Englisch)
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by...
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Klappentext zu „Abeta Peptide and Alzheimer's Disease “
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.
Inhaltsverzeichnis zu „Abeta Peptide and Alzheimer's Disease “
- A Brief Introduction to the History of the ß-Amyloid Protein (Aß) of Alzheimer's Disease (AD)- The Aßcentric Pathway of AD
- The Function of the Amyloid Precursor Protein Family
- The involvement of Aß in the neuroinflammatory response
- Amyloid ß-Peptide(1-42), Oxidative Stress, and AD
- Amyloid Toxicity, Synaptic Dysfunction and the Biochemistry of Neurodegeneration in AD
- Aß Variants and Their Impact on Amyloid Formation and AD Progression
- Copper Coordination by ß-Amyloid and the Neuropathology of AD
- Cholesterol and AD
- Amyloid ß peptide and central cholinergic neurons: involvement in normal brain function and AD pathology
- Physiological and Neurotoxic Properties of Aß Peptides
- Impact of ß-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models
- Glial Cells and Aß Peptides in AD Pathogenesis
- The Role of Presenilins in Abeta-Induced Cell Death in AD
- Immunotherapeutic approaches to AD
- Mouse Models of AD.
Bibliographische Angaben
- 2007, 2007, 298 Seiten, 70 Abbildungen, Maße: 21,5 x 28,5 cm, Gebunden, Englisch
- Herausgegeben:Barrow, Colin J; Small, David H.
- Herausgegeben: David H. Small, Colin J. Barrow
- Verlag: Springer, London
- ISBN-10: 1852339616
- ISBN-13: 9781852339616
- Erscheinungsdatum: 18.12.2006
Sprache:
Englisch
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