Acute Myelogenous Leukemia
Genetics, Biology and Therapy
(Sprache: Englisch)
Acute myelogenous leukemia (AML) is the most common form of leukemia in adults and is a deadly form of malignancy. This book details the work of pioneers in genetic mechanisms, targeted therapy, biology and mouse models for acute myelogenous leukemia.
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Acute myelogenous leukemia (AML) is the most common form of leukemia in adults and is a deadly form of malignancy. This book details the work of pioneers in genetic mechanisms, targeted therapy, biology and mouse models for acute myelogenous leukemia.
Klappentext zu „Acute Myelogenous Leukemia “
Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered.
Inhaltsverzeichnis zu „Acute Myelogenous Leukemia “
- AML Stem Cells- Chromosomal translocations in AML
- Chromosomal deletions in AML
- Secondary AML
- Novel molecular classification schemes and genes predictive of outcome in AML
- Tyrosine kinase fusions in AML.-Biology and therapy
- Core binding factor mutations
- Lineage specific transcription factor aberrations in AML
- APL, a paradigm for differentiation therapy
- Epigenetic mechanisms in AML
- AML and apoptosis
- Mouse models for AML
- Zebra fish model for AML
- Immunotherapy of AML
- Drug therapy of AML- Index
Autoren-Porträt
Lalitha Nagarajan is an Associate Professor, Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Bibliographische Angaben
- 2009, IX, 280 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Lalitha Nagarajan
- Verlag: Springer, Berlin
- ISBN-10: 0387692576
- ISBN-13: 9780387692579
- Erscheinungsdatum: 18.11.2009
Sprache:
Englisch
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