Advances in Research on Neurodegeneration
(Sprache: Englisch)
This volume highlights recent advances in the research of neurodegenerative processes and cell death. Also the role of inflammation in neurodegenerative processes is elucidated. A respectable number of articles deals with neuroprotective/neuroregenerative...
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This volume highlights recent advances in the research of neurodegenerative processes and cell death. Also the role of inflammation in neurodegenerative processes is elucidated. A respectable number of articles deals with neuroprotective/neuroregenerative strategies. Although most of this work is preclinical, there is also first evidence from clinical studies that neuroprotection should be possible in neurodegenerative disorders such as Parkinson's disease, amyotropic lateral sclerosis, Huntington's Chorea and eventually also Alzheimer's disease. Top scientists and international opinion leaders discussed and lectured at the 8th International Winter Conference on Neurodegeneration (IWCN) in Tegernsee, Bavaria, Germany, from February 9-13, 2000. And they have put together a valuable, comprehensive and timely piece of work that reviews all the above-mentioned problems and tries to evaluate therapeutic strategies of the future.
Klappentext zu „Advances in Research on Neurodegeneration “
The 8th International Winter Conference on Neurodegeneration from Febru ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany. The interest shown in this symposium, which was carried by invited speakers only, was striking. 28 lectures in 5 sessions dealt with themes on basic science and therapy strategies for neurodegenerative illness. This time especially basic mechanism of cell death and resulting causal treatment possibilities were centre themes of the lectures and lively discussions. In accordance with tradi tion 5 lectures on Multiple Sclerosis finished the convention. 60 scientists from 13 countries discussed current questions to these themes. The Symposium started with a lecture on the history of the develop ment of modern-L-DOPA-therapy. Lectures on cell death of dopaminergic nerve cells, new valuation regarding assembly, built up and function of neuromelanin of Substantia nigra and with this, the question of the physio logic and pathobiochemical role of dopamine and neuromelanin built the first block of themes which consequently extended to molecular and genetic aspects of cell death. Highlights of the symposium were neuroprotective and neuroregenerative future therapy strategies together with discussions on the difficulties of clinical neuroprotection. Developmental biological aspects on nerve cells, reorganisation and neurodegeneration showed a stimulating point of view of momentary and future development possibilities of new and more causal forms of therapy of neurodegenerative illness.
This volume highlights recent advances in the research of neurodegenerative processes and cell death. Also the role of inflammation in neurodegenerative processes is elucidated. A respectable number of articles deals with neuroprotective/neuroregenerative strategies. Although most of this work is preclinical, there is also first evidence from clinical studies that neuroprotection should be possible in neurodegenerative disorders such as Parkinson's disease, amyotropic lateral sclerosis, Huntington's Chorea and eventually also Alzheimer's disease. Top scientists and international opinion leaders discussed and lectured at the 8th International Winter Conference on Neurodegeneration (IWCN) in Tegernsee, Bavaria, Germany, from February 9-13, 2000. And they have put together a valuable, comprehensive and timely piece of work that reviews all the above-mentioned problems and tries to evaluate therapeutic strategies of the future.
Inhaltsverzeichnis zu „Advances in Research on Neurodegeneration “
Foley, P.: The L-DOPA story revisited. Further surprises to be expected? Jellinger, K. A., Stadelmann, Ch.: The enigma of cell death in neurodegenerative disorders
Double, K. L., Gerlach, M., Youdim, M. B. H., Riederer, P.: Impaired iron homeostasis in Parkinsons disease
Barzilai, A., Zilkha-Falb, R., Daily, D., Stern, N., Offen, D., Ziv, I., Melamed, E., Shirvan, A.: The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity
Tatton, W. G., Chalmers-Redman, R. M. E., Elstner, M., Leesch, W., Jagodzinski, F. B., Stupak, D. P., Sugrue, M. M., Tatton, N. A.: Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling
Hattori, N., Shimura, H., Kubo, S., Wang, M., Shimizu, N., Tanaka, K., Mizuno, Y.: Importance of familial Parkinsons disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinsons disease
Mandel, S., Grünblatt, E., Youdim, M.: cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinsons disease
Brooks, D. J.: Monitoring neuroprotection and restorative therapies in Parkinsons disease with PET Kitani, K., Minami, C., Maruyama, W., Kanai, S., Ivy, G. O., Carrillo, M.-C.: Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl
Weinstock, M., Bejar, C., Wang, R-H., Poltyrev, T., Gross, A., Finberg, J. P. M., Youdim, M. B. H.: TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimers disease
Maruyama, W., Akao, Y., Youdim, M. B. H., Naoi, M.: Neurotoxins induce apoptosis in dopamine neurons: protection bei N-propargylamine-1(R)- and (S)-aminoindan, rasagilline and TV1022
Bleich, S.,
... mehr
Degner, D., Javaheripour, K., Kurth, C., Kornhuber, J.: Homocysteine and alcoholism Waldmeier, P. C., Boulton, A. A., Cools, A. R., Kato, A. C., Tatton, W. G.: Neurorescuing effects of the GAPDH ligand CGP 3466B
Andringa, G., Cools, A. R.: The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinsons disease, the bilaterally MPTP-treated rhesus monkey Belluardo, N., Mudo, G., Blum, M., Amato, G., Fuxe, K.: Neurotrophic effects of central nicotinic receptor activationGötz, R.: Regulation of neuronal cell death and differentiation by NGF and IAP family members
Zheng, W.-H., Kar, S., Doré, S., Quirion, R.: Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway
Strelau, J., Böttner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K.: GDF-15/MIC-1 a novel member of the TGF-b superfamily
Nagatsu, T., Mogi, M., Ichinose, H., Togari, A.: Changes in cytokines and neurotrophins in Parkinsons disease
Wolters, E. Ch.: Psychiatric complications in Parkinsons disease
Ransmayr, G.: Dementia with Lewy bodies: prevalance, clinical spectrum and natural history
Teuchert-Noodt, G.: Neuronal degeneration and reorganization: a mutual prin-ciple in pathological and in healthy interactions of limbic and prefrontal circuits
Stefanova, N., Seppi, K., Scherfler, C., Puschban, Z., Wenning, G. K.: Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment
Mössner, R., Schmitt, A., Syagailo, Y., Gerlach, M., Riederer, P., Lesch, K. P.: The serotonin transporter in Alzheimers and Parkinsons disease
Berger, T., Reindl, M.: Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis
Martin, R., Bielekova, B., Gran, B., McFarland, H. F.: Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis
Werner, P., Pitt, D., Raine, C. S.: Glutamate excitotoxicity a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?
Floyd, R. A., Hensley, K., Bing, G.: Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics
Subject Index
Listed in Current Contents / Life Sciences
Andringa, G., Cools, A. R.: The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinsons disease, the bilaterally MPTP-treated rhesus monkey Belluardo, N., Mudo, G., Blum, M., Amato, G., Fuxe, K.: Neurotrophic effects of central nicotinic receptor activationGötz, R.: Regulation of neuronal cell death and differentiation by NGF and IAP family members
Zheng, W.-H., Kar, S., Doré, S., Quirion, R.: Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway
Strelau, J., Böttner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K.: GDF-15/MIC-1 a novel member of the TGF-b superfamily
Nagatsu, T., Mogi, M., Ichinose, H., Togari, A.: Changes in cytokines and neurotrophins in Parkinsons disease
Wolters, E. Ch.: Psychiatric complications in Parkinsons disease
Ransmayr, G.: Dementia with Lewy bodies: prevalance, clinical spectrum and natural history
Teuchert-Noodt, G.: Neuronal degeneration and reorganization: a mutual prin-ciple in pathological and in healthy interactions of limbic and prefrontal circuits
Stefanova, N., Seppi, K., Scherfler, C., Puschban, Z., Wenning, G. K.: Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment
Mössner, R., Schmitt, A., Syagailo, Y., Gerlach, M., Riederer, P., Lesch, K. P.: The serotonin transporter in Alzheimers and Parkinsons disease
Berger, T., Reindl, M.: Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis
Martin, R., Bielekova, B., Gran, B., McFarland, H. F.: Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis
Werner, P., Pitt, D., Raine, C. S.: Glutamate excitotoxicity a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?
Floyd, R. A., Hensley, K., Bing, G.: Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics
Subject Index
Listed in Current Contents / Life Sciences
... weniger
Bibliographische Angaben
- 2000, 2000, 421 Seiten, Maße: 21,5 x 28,6 cm, Gebunden, Englisch
- Ed. by Peter Riederer, Donald B. Calne, R. Horowski et al.
- Herausgegeben: R. Horowski, M. B. H. Youdim, C. W. Olanow, P. Riederer, Y. Mizuno, W. Poewe, D. B. Calne
- Verlag: Springer
- ISBN-10: 3211835385
- ISBN-13: 9783211835388
- Erscheinungsdatum: 13.12.2000
Sprache:
Englisch
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