Amyloid and Related Disorders

Introduction/general.- Aspects of the history and nomenclature of amyloid and amyloidosis.- Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis.- AA amyloidosis.- Non-Immunoglobulin and non-AA amyloidoses.- The hereditary amyloidoses.- Dialysis-associated amyloidosis.- Localized amyloidoses and amyloidoses associated with aging outside the central nervous system.- Central nervous system amyloid.- Non-amyloid protein deposits.- Differential diagnosis of amyloid in surgical pathology: organized deposits and other material in the differential diagnosis of amyloidosis.- Light /heavy chain deposition disease as a systemic disease.- Glomerulonephritis with non-organized monoclonal immunoglobulin deposits.- Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond.- Diagnosis.- Diagnosis of amyloid using Congo red - polarized and fluorescence.- Thioflavin T stain for amyloid detection.- Fat tissue analysis in the management of patients with systemic amyloidosis.- Generic diagnosis of amyloid - recent developments and summary of current recommendations.- Amyloid typing on formalin-fixed paraffin sections by immunohistochemistry - experience from two large referral centers.- Options for amyloid typing in renal pathology - the advantages of frozen section immunofluorescence.- Amyloid typing by immuno-electron microscopy.- Classification of amyloidosis by mass spectrometry-based proteomics.- Summary and practical recommendation regarding amyloid typing using antibody-based and proteomic methods.- Ancillary studies of amyloidosis.- Laboratory support for diagnosis of amyloidosis.- Bone marrow biopsy and its utility in the diagnosis of AL amyloidosis and other plasma cell dyscrasias.- Molecular methods for the diagnosis of hereditary amyloidosis.- Radiologic support for diagnosis and monitoring of amyloidosis - established techniques and recent developments.- Organ involvement inamyloidoses.- Amyloidoses of

Maria M. Picken, MD, PhD

Professor of Pathology

Director of Surgical Pathology

Past President Renal Pathology Society

Loyola University Medical Center

Department of Pathology

2160 South First Avenue, Building 110, Room 2242

Maywood, IL

USA

Guillermo A. Herrera, M.D.

Albert G. And Harriet G. Smith Professor and Chair

LSU Health Shreveport

Department of Pathology

1501 Kings Highway

Shreveport, LA 

USA

Ahmet Dogan, MD, PhD

Chief, Hematopathology Service

Memorial Sloan Kettering Cancer Center

Department of Pathology and Laboratory Medicine

1275 York Avenue

New York, NY 

USA