Anoikis
How the Extracellular Matrix Regulates Life-or-Death Decisions
(Sprache: Englisch)
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In...
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Klappentext zu „Anoikis “
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.
Inhaltsverzeichnis zu „Anoikis “
PrefaceIntroductionChapter 1 The intersection of anoikis resistance and fatty acid metabolism in cancerChapter 2 Anoikis resistance in melanomaChapter 3 Anoikis mediated by stress-activated MAPK signaling pathwaysChapter 4 Metabolic Regulation of AnoikisChapter 5 Metabolic Reprogramming contributes to Anoikis resistance in Cancer CellsChapter 6 Role of the nuclear receptors in anoikisChapter 7 The roles of anoikis in cervical cancerChapter 8 Shc and the control of small GTPase dynamics in cellular anchorageChapter 9 Anoikis and the Human Gut Epithelium in Health and DiseaseChapter 10 Epithelial cell extrusion: the prelude to anoikisChapter 11 Microtubule modifications and mitochondria: role in anoikis
Autoren-Porträt
Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.
Bibliographische Angaben
- 2021, 1st ed. 2021, VIII, 202 Seiten, Maße: 15,5 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Steven M. Frisch
- Verlag: Springer, Berlin
- ISBN-10: 303073854X
- ISBN-13: 9783030738549
Sprache:
Englisch
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