Arachidonic Acid Metabolism and Tumor Initiation
(Sprache: Englisch)
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time,...
Leider schon ausverkauft
versandkostenfrei
Buch
213.99 €
Produktdetails
Produktinformationen zu „Arachidonic Acid Metabolism and Tumor Initiation “
Klappentext zu „Arachidonic Acid Metabolism and Tumor Initiation “
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Inhaltsverzeichnis zu „Arachidonic Acid Metabolism and Tumor Initiation “
1. Metabolism and the "Initiation" of Tumors by Chemicals.- 2. Arachidonic Acid Metabolism and Tumor Initiation.- 3. Arachidonic Acid-Dependent Metabolism of Chemical Carcinogens and Toxicants.- 4. Prostaglandin Synthase-Dependent Cooxidation and Aromatic Amine Carcinogenesis.- 5. Involvement of Prostaglandin Synthase in the Metabolic Activation of Acetaminophen and Phenacetin.
Bibliographische Angaben
- Autor: Lawrence J. Marnett
- 1985, 200 Seiten, mit zahlreichen Abbildungen, Maße: 15,6 x 23,4 cm, Gebunden, Englisch
- Verlag: Springer
- ISBN-10: 0898387299
- ISBN-13: 9780898387292
Sprache:
Englisch
Kommentar zu "Arachidonic Acid Metabolism and Tumor Initiation"
0 Gebrauchte Artikel zu „Arachidonic Acid Metabolism and Tumor Initiation“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Arachidonic Acid Metabolism and Tumor Initiation".
Kommentar verfassen