Basic Pharmacokinetics and Pharmacodynamics

Preface xix
 
Contributors xxi
 
1 Introduction to Pharmacokinetics and Pharmacodynamics 1
Sara E. Rosenbaum
 
1.1 Introduction: Drugs and Doses, 2
 
1.2 Introduction to Pharmacodynamics, 3
 
1.3 Introduction to Pharmacokinetics, 9
 
1.4 Dose-Response Relationships, 12
 
1.5 Therapeutic Range, 14
 
1.6 Summary, 18
 
Reference, 18
 
2 Passage of Drugs Through Membranes 19
Sara E. Rosenbaum
 
2.1 Introduction, 20
 
2.2 Structure and Properties of Membranes, 20
 
2.3 Passive Diffusion, 21
 
2.4 Carrier-Mediated Processes: Transport Proteins, 26
 
References, 33
 
3 Drug Administration and Drug Absorption 35
Steven C. Sutton
 
3.1 Introduction: Local and Systemic Drug Administration, 36
 
3.2 Routes of Drug Administration, 37
 
3.3 Overview of Oral Absorption, 41
 
3.4 Extent of Drug Absorption, 44
 
3.5 Determinants of the Fraction of the Dose Absorbed (F), 46
 
3.6 Factors Controlling the Rate of Drug Absorption, 61
 
3.7 Biopharmaceutics Classification System, 64
 
3.8 Food Effects, 65
 
Problems, 66
 
References, 67
 
4 Drug Distribution 71
Sara E. Rosenbaum
 
4.1 Introduction, 72
 
4.2 Extent of Drug Distribution, 72
 
4.3 Rate of Drug Distribution, 89
 
4.4 Distribution of Drugs to the Central Nervous System, 93
 
Problems, 96
 
References, 98
 
5 Drug Elimination and Clearance 99
Sara E. Rosenbaum
 
5.1 Introduction, 100
 
5.2 Clearance, 102
 
5.3 Renal Clearance, 108
 
5.4 Hepatic Elimination and Clearance, 119
 
Problems, 139
 
References, 142
 
6 Compartmental Models in Pharmacokinetics 145
Sara E. Rosenbaum
 
6.1 Introduction, 146
 
6.2 Expressions for Component Parts of the Dose-Plasma Concentration Relationship, 146
 
6.3 Putting Everything

Sara E. Rosenbaum, PhD, is Professor of Biomedical and Pharmaceutical Sciences at the University of Rhode Island, where she teaches courses in pharmacokinetics and pharmacodynamics. Her research interests concentrate on the development and application of pharmacokinetic and pharmacodynamic models to better understand the drug dose-response relationship.