Bioactive Heterocyclic Compound Classes. Agrochemicals

IINTRODUCTIONTHE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALSIntroductionHeterocycles as Framework of Biologically Active CompoundsFine-Tuning the Physicochemical Properties with HeterocyclesHeterocycles as ProdrugsHeterocycles as PeptidomimeticsHeterocycles as Isosteric Replacement of Functional GroupsHeterocycles as Isosteric Replacement of Alicyclic RingsHeterocycles as Isosteric Replacement of other Heterocyclic RingsPART I: HerbicidesTRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction HistorySynthesisMode of Action Biological Activity Structure?Activity Relationship HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES IntroductionHistory SynthesisMode of ActionBiological Activity Structure?Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COA CARBOXYLASEIntroduction HistorySynthesis Mode of Action Biological Activity Structure?Activity Relationships IMIDAZOLINONE HERBICIDESIntroduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship Part II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDESIntroduction History Synthesis Mode of Action Biological Activity Structure?Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES

Clemens Lamberth is a senior team leader in the crop protection research department of Syngenta AG, Switzerland. He studied chemistry at the Technical University of Darmstadt, Germany, where he obtained his Ph.D. under the supervision of Prof. Bernd Giese in 1990. Subsequently, he spent one and a half years as a postdoctoral fellow in the group of Prof. Mark Bednarski at the University of California at Berkeley, U.S.A. In 1992 Clemens Lamberth joined the agrochemical research department of Sandoz Agro AG, Switzerland, which is today, after two mergers, part of Syngenta Crop Protection AG. Since 20 years he is specialized in fungicide discovery. He was the organizer of the two-day session 'New Trends for Agrochemicals' at the 2nd EUCHEMS congress in Torino 2008. He is the author of 46 publications and 56 patents and the inventor of Syngenta's fungicide mandipropamid (Revus®, Pergado®).Jürgen Dinges obtained his M.S. degree in organic chemistry at the Technical University in Darmstadt, Germany in 1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the same University, where he received his Ph.D. degree in organic chemistry and chemical engineering in 1991. After being awarded a Feodor-Lynen scholarship from the Humboldt foundation, he spent 18 months as a postdoctoral fellow in the group of Prof. William G. Dauben at the University of California at Berkeley, U.S.A. In 1993, Jurgen Dinges joined the department for biochemistry at Syntex, U.S.A. and since 1995 he is working in the pharmaceutical research department at Abbott Laboratories, U.S.A. In 2009, he was a guest editor for Current Topics in Medicinal Chemistry for a special issue on Parkinson?s disease. He is an author of 17 publications and 23 patents and a co-inventor of more than 10 clinical drug development candidates.