Biochemical Pathways

Preface to the Second Edition IX From the Preface to the First Edition X Contributors XI 1 Introduction and General Aspects 1 Gerhard Michal and Dietmar Schomburg 1.1 Organization of This Book 1 1.2 Carbohydrate Chemistry and Structure 4 1.3 Amino Acid Chemistry and Structure 5 1.4 Lipid Chemistry and Structure 6 1.5 Physico-Chemical Aspects of Biochemical Processess 8 2 The Cell and Its Contents 14 Gerhard Michal and Dietmar Schomburg 2.1 Classification of Living Organisms 14 2.2 Structure of Cells 14 2.3 Protein Structure and Function 18 2.4 Enzymes 21 2.5 Regulation of the Enzyme Activity 24 2.6 Nucleic Acid Structure 26 2.7 Genetic Code and the Flow of Information 30 2.8 Polymeric Carbohydrates 31 2.9 Glycosylated Proteins and Peptides 32 2.10 Lipid Aggregates and Membranes 35 3 Metabolism 37 3.1 Carbohydrate Metabolism and Citrate Cycle 37 Röbbe Wünschiers 3.2 Amino Acids and Derivatives 58 Röbbe Wünschiers 3.3 Tetrapyrroles 82 Martina Jahn and Dieter Jahn 3.4 Lipids and Glycolipids 93 Röbbe Wünschiers 3.5 Steroids and Isoprenoids 107 Röbbe Wünschiers 3.6 Nucleotides and Nucleosides 124 Röbbe Wünschiers 3.7 Cofactors and Vitamins 133 Ida Schomburg 3.8 Nucleic Acid Metabolism in Bacteria 149 Susanne Peifer and Elmar Heinzle 3.9 Nucleic Acid Metabolism in Eukarya 157 Helmut Burtscher 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 164 Julia Garbe, Annika Steen and Max Schobert 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 183 Martina Jahn and Dieter Jahn 3.12 Photosynthesis 188 Dieter Oesterhelt and Josef Wachtveitl 3.13 Plant Secondary Metabolism 193 Antje Chang 4 Protein Biosynthesis, Modifications and Degradation 210 4.1 Protein Synthesis in Bacteria 210 Martina Jahn and Dieter Jahn 4.2 Protein Biosynthesis in Eukarya 219 Röbbe Wünschiers 4.3 Cell Cycle in Eukarya 232 Stefan Ries 4.4 Posttranslational Modification of Proteins 238 Röbbe Wünschiers 4.5 Protein Folding, Transport / Targeting and Degradation 244 Petra Dersch 5

GERHARD MICHAL, PhD, has retired from research at Boehringer Mannheim GmbH (now Roche Diagnostics). He is internationally acclaimed for developing the "Biochemical Pathways" wall chart. The first edition, which was published some forty years ago, has been continuously updated and is used in many biochemistry laboratories around the world. DIETMAR SCHOMBURG, PhD, is a Full Professor and Head of the Department of Bioinformatics and Biochemistry at the Technische Universität Carolo-Wilhelmina in Braunschweig. His research interests include protein structure and function, structural biochemistry, bioinformatics, and enzyme information/metabolic networks. Dr. Schomburg has been widely praised for establishing BRENDA, the principal source of enzyme function and property data.

"...highly recommended for every scientist and student working in biochemistry." - Umwelt & Gesundheit 4/2012 (review in German)

"Michal and Schomburg (Technische Univ. Carolo-Whilhelmina, Germany) have reorganized, updated, and greatly expanded (over 100 pages of new content) this unique resource, keeping it an essential biochemical reference. Summing Up: Essential. Biochemistry collections, upper-division undergraduates through professionals." (Choice, 1 August 2013)
 
"Biochemical Pathways, Second Edition is recommended for all students and researchers in such fields as biochemistry, molecular biology, medicine, organic chemistry, and pharmacology. The book's illustrated pathways aids the reader in understanding the complex set of biochemical reactions that occur in biological systems." (Kingbook73.blogspot, 23 April 2013)
 
"This book, not too scary to read thanks to its compact size, served as a great reading for the incoming graduate students from the biology department and the chemical engineering department alike." (Biotechnology Journal, 1 January 2013)