Biology and Treatment of Leukemia and Bone Marrow Neoplasms
(Sprache: Englisch)
This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a...
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Klappentext zu „Biology and Treatment of Leukemia and Bone Marrow Neoplasms “
This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.Inhaltsverzeichnis zu „Biology and Treatment of Leukemia and Bone Marrow Neoplasms “
Advances in diagnosis and risk stratification of leukemias and bone marrow neoplasms.- Genetics and diagnostic approach to lymphoblastic leukemia.- Acute promyelocytic leukemia: update on risk stratification and treatment.- Current and emerging therapies for AML.- Current management and new developments in treatment of ALL.- Contemporary therapy of CML.- MDS: Pathogenesis and therapy.- Chronic lymphocytic leukemia: Biology and therapy.- Biology and current treatment of Myeloproliferative neoplasms.- Systemic Mastocytosis: Pathology and treatment.- Adoptive T-cell therapy and other novel immunotherapies for leukemia.
Autoren-Porträt
Guido Marcucci, MD, is Chair and Professor in the Department of Hematologic Malignancies Translational Science and Professor in the Department of Hematology and Hematopoietic Stem Cell Transplantation at City of Hope (COH) Comprehensive Cancer Center in California. He is also Director of the Gehr Family Center for Leukemia Research at COH. Dr. Marcucci has conducted basic, translational, and clinical research in myeloid malignancies. His research focus has been on discovery of basic mechanisms of leukemogenesis, novel therapeutic targets, epigenetic and genetic prognostic biomarkers, and new drug development for AML and MDS. He has chaired several phase I, II, and III clinical trials as both single- and multi-institution studies within the oncology cooperative group Alliance (formerly known as CALGB), for which he is currently Vice-Chair of the Leukemia Committee and Member of the Leukemia Correlative Science Committee. Dr. Marcucci has published over 300 papers in peer-reviewed journals and has been uninterruptedly funded by the National Cancer Institute since 2001.
Bibliographische Angaben
- 2021, 1st ed. 2021, VIII, 196 Seiten, 14 farbige Abbildungen, Maße: 15,5 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Vinod Pullarkat, Guido Marcucci
- Verlag: Springer, Berlin
- ISBN-10: 3030783103
- ISBN-13: 9783030783105
Sprache:
Englisch
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