Bone Metastases

Preface. I FUNDAMENTAL CONCEPTS.1 Pathophysiology of metastatic bone disease. 2 Bone metastases: epidemiology, clinical picture, SREs and prognosis. 3 Pain in bone metastases: types and mechanisms. II INVESTIGATIONS OF BONE METASTASES. 4 Radiological evaluations: radiography, CT, MRI. 5 Nuclear medicine imaging modalities: bone scintigraphy, PET-CT, SPECT. 6. Bone turnover markers. 7. New omics approaches for bone metastases. III THERAPEUTIC MANAGEMENT. 8 Analgesic treatment for bone mets. 9. Radiotherapy: external beam and radio-surgery. 10 Radionuclide therapy.11. Bisphosphonates. 12 New targeted therapies for bone metastases. 13. Chemotherapy and hormone therapy. 14 HIFU/Radioablation. 15 Neuropathic bone metastases. 16. Spinal cord compression and cauda equina compression. 17 Pathological and impending fracture. 18 Re-irradiation. 19. Bone metastases in elderly patients. 20. Management of metastatic bone disease in the elderly with bisphosphonates and RANKL inhibitors: effectiveness and safety. IV ASSESMENT OF THERAPEUTIC RESPONSE. 21 Radiological and nuclear medicine imaging modalities. 22 Clinical assessment measures. 23 Outcome measures in bone metastases clinical trials. 24 Quality of life in patients suffering from metastatic skeletal disease. V COST OF MANAGING METASTATIC BONE DISEASE. 25 Cost effectiveness of treatment modalities for bone metastases. Index.