Cell Growth and Oncogenesis

Ion homeostasis, energy metabolism and control of cell growth.- Glucose catabolism in cancer cells: Role and regulation of hexokinase overexpression.- Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools.- The mitochondrial ATP synthase in normal and neoplastic cell growth.- The pH of internal compartments of normal and activated cells.- Signal transduction, oncogenes and growth factors.- Hepatic regeneration: New concepts on cell proliferation.- Raf-dependent signaling pathways in cell growth and differentiation.- E7 protein of human papillomaviruses and its interaction with cellular pathways.- Phosphorylation of the p53 tumour suppressor protein by stress- and DNA damage-activated protein kinases.- Bile acids, cell proliferation and protein phosphorylation.- Alteration of cell division cycle regulation in human cancers: The role of CDKN2A gene.- The bombesin receptor is coupled to multiple signal transduction pathways and induces cell proliferation.- Control of cell proliferation by a-tocopherol.- Development of resistance to the mitoinhibitory effects of orotic acid during experimental liver carcinogenesis.- Mechanisms of carcinogenesis and drug resistance of cancer cells.- Early aberrations of energy metabolism in carcinogenesis.- Stimulation of liver cell growth by direct mitogens.- Low-number intrahepatic islet transplantation - a model of hormonal hepatocarcinogenesis.- Translational regulation: possible significance of differential tRNA expression during the transition from quiescence to proliferation.- Cloning and expression of a stable ornithine decarboxylase form conferring selective growth advantage to the HMOA cells against cytostatic treatment with ?-methylornithine.- Changing the lipid composition in hepatoma cell membranes can affect cell death and proliferation.- The multidrug resistance phenotype: P-glycoprotein, regulation of the mdr genes and other related mechanisms.