Clinical Pharmacology in the Elderly
Reference Ranges and Biological Variations After Repeated Measurements
(Sprache: Englisch)
The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase...
Leider schon ausverkauft
versandkostenfrei
Buch
85.55 €
42 DeutschlandCard Punkte
sammeln
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „Clinical Pharmacology in the Elderly “
Klappentext zu „Clinical Pharmacology in the Elderly “
The appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude .... :''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.
Inhaltsverzeichnis zu „Clinical Pharmacology in the Elderly “
1 Introduction.- 2 Theories of Aging.- 3 Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age.- 3.1 Changes in Central Nervous System.- 3.1.1 Brain Structure and Function.- 3.1.2 Electroencephalogram.- 3.1.2 Cognitive Performance and Behavior.- 3.2 Cardiovascular and Pulmonary Changes.- 3.2.1 Heart.- 3.2.2 Blood Pressure.- 3.2.3 Arrhythmias.- 3.2.4 Lung.- 3.3 Changes in Clinical Chemistry and Hematology.- 3.3.1 Clinical Chemistry.- 3.3.2 Hematology.- 3.3.3 Repeated Measurements of Clinical Chemistry and Hematological Variables.- 3.3.4 Biological Rhythms.- 3.4 Changes in Pharmacokinetics.- 3.4.1 Absorption.- 3.4.2 Distribution.- 3.4.3 Protein Binding.- 3.4.4 Metabolism.- 3.4.5 Excretion.- 3.5 Changes in Receptor Sensitivity.- 4 Practical Aspects in Performing Clinical Trials in Elderly Subjects.- 4.1 Recruitment of Subjects.- 4.2 Performance of the Study.- 4.3 Safety Aspects.- 4.4 Sample Size.- 4.5 Compliance of Subjects with Medication and Study Regulations.- 5 Experimental Findings in Elderly Subjects.- 5.1 Method.- 5.1.1 Inclusion Criteria.- 5.1.2 Exclusion Criteria.- 5.1.3 Technical Methods.- 5.1.4 Data Management and Statistics.- 5.2 Experimental Data.- 5.2.1 Blood Pressure and Pulse Rate.- 5.2.2 Ambulatory Blood Pressure Monitoring.- 5.2.3 ECG Times.- 5.2.4 Ambulatory ECG Monitoring.- 5.2.5 Spirometry (FEV1).- 5.2.6 Clinical Chemistry.- 5.2.7 Hematology.- 5.2.8 Adverse Events.- 5.3 Consequences from Experimental Data in Healthy Subjects.- 6 Statistical Details.- 6.1 Blood Pressure.- 6.1.1 Baseline Values.- 6.1.2 Changes During Study Day.- 6.1.3 Changes After Repeated Measurements.- 6.2 Ambulatory Blood Pressure Monitoring.- 6.2.1 Baseline Values.- 6.2.2 Changes After 2 Weeks.- 6.3 ECG Times.- 6.3.1 Baseline Values.- 6.3.2 Changes During Study Day.- 6.3.3 Changes After Repeated Measurements.- 6.4 Ambulatory ECG Monitoring.- 6.4.1 Baseline Values.- 6.4.2 Changes After 2-3 Weeks.- 6.5 Spirometry (FEV1).- 6.5.1 Baseline Values.-6.5.2
... mehr
Changes During Study Day and After 1 Week.- 6.6 Clinical Chemistry.- 6.6.1 Baseline Values.- 6.6.2 Changes After Repeated Measurements.- 6.7 Hematology.- 6.7.1 Baseline Values.- 6.7.2 Changes After Repeated Measurements.- References.
... weniger
Bibliographische Angaben
- Autor: Hans-Peter Breuel
- 1995, Softcover reprint of the original 1st ed. 1996., 182 Seiten, Maße: 23,5 cm, Kartoniert (TB), Englisch
- Mitarbeit: Kuhlmann, J.; Heine, P.R.; Horkulak, J.; Weyer, G.
- Verlag: Springer
- ISBN-10: 3540594957
- ISBN-13: 9783540594956
Sprache:
Englisch
Kommentar zu "Clinical Pharmacology in the Elderly"
0 Gebrauchte Artikel zu „Clinical Pharmacology in the Elderly“
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "Clinical Pharmacology in the Elderly".
Kommentar verfassen