Concepts and Case Studies in Chemical Biology
(Sprache: Englisch)
Retaining the proven didactic concept of its predecessor, this sequel features 27 new case studies taken from everyday lab work, each elucidated by an international team of renowned scientists. An introduction to modern approaches, results, and methods in chemical biology.
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Retaining the proven didactic concept of its predecessor, this sequel features 27 new case studies taken from everyday lab work, each elucidated by an international team of renowned scientists. An introduction to modern approaches, results, and methods in chemical biology.
Klappentext zu „Concepts and Case Studies in Chemical Biology “
Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years.Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists.With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.
Inhaltsverzeichnis zu „Concepts and Case Studies in Chemical Biology “
Introduction and PrefaceAbbreviationsREAL-TIME AND CONTINUOUS SENSORS OF PROTEIN KINASE ACTIVITY UTILIZING CHELATION-ENHANCED FLUORESCENCEIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionsFLiK AND FLiP: DIRECT BINDING ASSAYS FOR THE IDENTIFICATION OF STABILIZERS OF INACTIVE KINASE AND PHOSPHATASE CONFORMATIONSIntroduction - The Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionsSTRATEGIES FOR DESIGNING SPECIFIC PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND THEIR INTRACELLULAR ACTIVATIONIntroduction - The Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionsDESIGN AND APPLICATION OF CHEMICAL PROBES FOR PROTEIN SERINE/THREONINE PHOSPHATASE ACTIVATIONIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionAUTOPHAGY: ASSAYS AND SMALL-MOLECULE MODULATORSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological EvaluationConclusionELUCIDATION OF PROTEIN FUNCTION BY CHEMICAL MODIFICATIONIntroductionThe Biological ProblemThe Chemical ApproachBiological Research/EvaluationConclusionINHIBITION OF ONCOGENIC K-Ras SIGNALING BY TARGETING K-Ras-PDEDeltaIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological EvaluationConclusionsDEVELOPMENT OF ACYL PROTEIN THIOESTERASE 1 (APT1) INHIBITOR PALMOSTATIN B THAT REVERT UNREGULATED H/N-Ras-SIGNALINGIntroductionThe Biological Problem - The Role of APT1 in Ras SignalingThe Chemical ApproachChemical Biological Research/EvaluationConclusionsFUNCTIONAL ANALYSIS OF HOST-PATHOGEN POSTTRANSLATIONAL MODIFICATION CROSSTALK OF RAB PROTEINSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionsCHEMICAL BIOLOGY APPROACH TO SUPPRESSION OF STATIN-INDUCED MUSCLE TOXICITYIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionA TARGET IDENTIFICATION
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SYSTEM BASED ON MORPHOBASE, CHEMPROTEOBASE, AND PHOTO-CROSS-LINKING BEADSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionACTIVITY-BASED PROTEASOME PROFILING IN MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGYIntroductionThe Biological ProblemThe Chemical ApproachBiological Research/EvaluationConclusionsRATIONAL DESIGN OF ACTIVITY-BASED RETAINING BETA-EXOGLUCOSIDASE PROBESIntroductionThe Biological ProblemThe Chemical ApproachBiological Research/EvaluationConclusionsMODULATION OF ClpP PROTEASE ACTIVITY: FROM ANTIBIOTICS TO ANTIVIRULENCEIntroductionThe Biological ProblemThe Chemical ApproachThe Discovery of a Novel Antibiotic MechanismThe Antivirulence ApproachConclusionsAFFINITY-BASED ISOLATION OF MOLECULAR TARGETS OF CLINICALLY USED DRUGSIntroduction - The Biological/Medicinal ProblemThe Chemical ApproachChemical Biological ResearchConclusionIDENTIFICATION OF THE TARGETS OF NATURAL-PRODUCT-INSPIRED MITOTIC INHIBITORSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological EvaluationConclusionFINDING A NEEDLE IN A HAYSTAY. IDENTIFICATION OF TANKYRASE, A NOVEL THERAPEUTIC TARGET OF THE WNT PATHWAY USING CHEMICAL GENETICSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionTHE IDENTIFICATION OF THE MOLECULAR RECEPTOR OF THE PLANT HORMONE ABSCISIC ACIDIntroductionThe Biological ProblemThe Chemical Genetics ApproachThe Chemical Biology ApproachConclusionCHEMICAL BIOLOGY IN PLANTS: FINDING NEW CONNECTIONS BETWEEN PATHWAYS USING THE SMALL MOLECULE SORTIN 1IntroductionThe Biological ProblemThe Chemical ApproachBiological Research/EvaluationConclusionSELECTIVE TARGETING OF PROTEIN INTERACTIONS MEDIATED BY BET BROMODOMAINSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological InvestigationsConclusionTHE IMPACT OF DISTANT POLYPHARMACOLOGY IN THE CHEMICAL BIOLOGY OF PARPSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionsSPLICING INHIBITORS: FROM SMALL MOLECULE TO RNA METABOLISMIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionPHOTOCHEMICAL CONTROL OF GENE FUNCTION IN ZEBRAFISH EMRYOS WITH LIGHT-ACTIVATED MORPHOLINOSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/EvaluationConclusionLIFE CELL IMAGING OF mRNA USING PNA FIT PROBESIntroductionThe Biological ProblemThe Chemical ApproachChemical Biological Research/ValidationConclusionTARGETING THE TRANSCRIPTIONAL HUB BETA-CATENIN USING STAPLED PEPTIDESIntroductionThe Biological ProblemThe Chemical Approach: Hydrocarbon Peptide StaplingThe Biological Approach: Phage-Display-Based OptimizationBiochemical and Biological EvaluationConclusionsDIVERSITY-ORIENTED SYNTHESIS: DEVELOPING NEW CHEMICAL TOOLS TO PROBE AND MODULATE BIOLOGICAL SYSTEMSIntroductionThe Biological ProblemThe Chemical ApproachChemical Biology ResearchConclusionSCAFFOLD DIVERSITY SYNTHESIS WITH BRANCHING CASCADES STRATEGYIntroductionThe Biological/Pharmacological Problem: Discovering Small Bioactive MoleculesThe Chemical Approach: Scaffold DiversityChemical/Biological Evaluation - Branching Cascades Strategy in Scaffold Diversity SynthesisConclusionsIndex
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Autoren-Porträt
Herbert Waldmann obtained his PhD in organic chemistry from the University of Mainz, Germany, in 1985 working with Professor H. Kunz, after which he completed a postdoctoral appointment with Professor G. Whitesides at Harvard University (USA). He was appointed as Professor of Organic Chemistry at the University of Bonn (1991), full Professor of Organic Chemistry at the University of Karlsruhe (1993), and Director at the Max-Planck-Institute of Molecular Physiology Dortmund and Professor of Organic Chemistry at the University of Dortmund, Germany, in 1999. He has received numerous awards, e.g. the Otto-Bayer-Award (2001), the Max Bergmann Medal (2003), and recently the Emil-Fischer-Prize (2012). His research interests lie in bioactive compound development, target identification, and the chemical biology of Ras proteins. Petra Janning studied chemistry at the University of Münster, Germany, and did her PhD thesis at the Institute for Analytical Sciences in Dortmund, Germany in 1995. After different positions where she worked in the area of analytical chemistry and on the borderline between chemistry and biology she joined the Max-Planck-Institute of Molecular Physiology, Dortmund, in the department of Professor H. Waldmann, where she is currently working. She is responsible for the Bioorganic Practical Course and the analytics in the department. She focused her work on mass spectrometry based methods in proteome research in particular in target protein identification of small molecules.
Bibliographische Angaben
- 2014, 464 Seiten, 20 farbige Abbildungen, 100 Schwarz-Weiß-Abbildungen, Maße: 17 x 24,3 cm, Kartoniert (TB), Englisch
- Herausgegeben: Herbert Waldmann, Petra Janning
- Verlag: Wiley-VCH
- ISBN-10: 3527336117
- ISBN-13: 9783527336111
- Erscheinungsdatum: 19.08.2014
Sprache:
Englisch
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