Endothelial Mechanisms of Vasomotor Control

Basic Physiology of EDRF.- Cellular mechanisms controlling EDRF/NO formation in endothelial cells.- EDRF: nitrosylated compound or authentic nitric oxide.- Does EDRF/NO regulate its own release by increasing endothelial cyclic GMP?.- Molecular mechanisms of nitrovasodilator bioactivation.- Angiogenesis in the adult heart.- The endothelium in control of blood flow in vivo.- Endothelium and blood flow mediated vasomotion in the conscious dog.- Endothelium-mediated regulation of coronary tone.- Role of EDRF and endothelium in coronary vasomotor control.- Blood flow and optimal vascular topography: role of the endothelium.- Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide.- Endothelial function in pathological conditions.- Endothelial dysfunction in myocardial ischemia and reperfusion: role of ogygen-derived free radicals.- Interactions between nitric oxide and prostacyclin in myocardial ischemia and endothelial cell cultures.- Effects of native and oxidized low-density lipoproteins on endothelium-dependent and endothelium-independent vasomotion.- Endothelium-dependent control of vascular tone: effects of age, hypertension and lipids.- Experimental induction of spasm, sudden progression of organic stenosis and intramural hemorrhage in the epicardial coronary arteries.- Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine.- Endothelial function in the clinical setting.- Assessment of coronary vasomotor tone in humans.- Coronary vasomotion and coronary flow reserve during exercise.- Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans.- Coronary vasospasm in humans: the role of atherosclerosis and of impaired endothelial vasodilator function.- Progression of coronary endothelial dysfunction in man and its potential clinical significance.- Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists.