Genetic Effects on Environmental Vulnerability to Disease
(Sprache: Englisch)
This book brings together contributions from experts from multiple disciplines who discuss: how epidemiological cohort studies can better integrate physiological (mechanistic) measures; how best to characterise subjects' vulnerability versus resilience by...
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This book brings together contributions from experts from multiple disciplines who discuss: how epidemiological cohort studies can better integrate physiological (mechanistic) measures; how best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms; how gene hunters can benefit from recruiting samples selected for known exposures; how environmental pathogens can be used as tools for gene hunting; how to deal with potential spurious (statistical) interactions; and how genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).
Klappentext zu „Genetic Effects on Environmental Vulnerability to Disease “
While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. An alternative approach is to incorporate information about the environment. The gene-environment interaction approach focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor.Genetic Effects on Environmental Vulnerability to Disease is based on the final meeting of the Novartis Foundation Symposium Series (#293 Understanding How Gene Environment Interactions Work to Predict Disorder). Contributions from geneticists, physicians, oncologists, biologists, statisticians, epidemiologists, psychiatrists and psychologists address:
* how physiological (mechanistic) measures can be better integrated into epidemiological cohort studies
* how best to characterise subjects' vulnerability versus resilience by moving beyond genetic main effects
* how gene hunters can benefit from recruiting samples selected for known exposures
* how environmental pathogens can be used as tools for gene hunting
* how to deal with potential spurious (statistical) interactions, and
* how genes can help explain fundamental demographic properties of disorders such as sex distribution or age effects.
Interwoven with transcripts of the lively discussions among researchers, the contents of the book offer a cutting-edge review of the methodological issues prevailing in this complex, multi-disciplinary field.
A glossary of technical terms helps facilitate understanding across the different disciplines involved, and Sir Michael Rutter's introduction and concluding remarks contribute to presenting scientific issues in an interesting, easily accessible manner.
This book will be of interest to epidemiologist,
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geneticists, developmental biologists, and researchers in psychiatric disorders, obesity, diabetes, cancer, respiratory diseases and cardiovascular disease
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Inhaltsverzeichnis zu „Genetic Effects on Environmental Vulnerability to Disease “
1. Michael RutterIntroduction: whither gene-environment interactions?
2. Rudolf Uher
Gene-environment interaction: overcoming methodologicalchallenges
Discussion
3. Marco Battaglia, Cecilia Marino, Michel Maziade, MassimoMolteni and Francesca D'Amato
Gene-environment interaction and behavioural disorders: adevelopmental perspective based on endophenotypes
Discussion
4. Naomi R. Wray, William L. Coventry, Michael R. James,Grant W. Montgomery, Lindon J. Eaves and Nicholas G.Martin
Use of monozygotic twins to investigate the relationship between5HTTLPR genotype, depression and stressful life events: anapplication of Item Response Theory
Discussion
Appendix
General discussion I
5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W.J. H. Penninx, Harriëtte Riese and Catharina A.Hartman
Role of gene-stress interactions in gene-findingstudies
Discussion
6. Kenneth A. Dodge
Practice and public policy in the era of gene-environmentinteractions
Discussion
7. Kristi B. Adamo and FrédériqueTesson
Gene-environment interaction and the metabolicsyndrome
Discussion
General discussion II
8. Stephen P. Robertson and RichiePoulton
Longitudinal studies of gene-environment interaction incommon diseases-good value for money?
Discussion
9. Kee-Seng Chia
Gene-environment interactions in breast cancer
Discussion
10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, SarahRowe, Robert W. Williams and Lu Lu
Unbiased forward genetics and systems biology approaches tounderstanding how gene-environment interactions work topredict susceptibility and outcomes of infections
Discussion
11. Steven R. Kleeberger and Hye-YounCho
Gene-environment interactions in environmental lungdiseases
Discussion
General discussion III
12. Fernando D. Martinez
Gene-environment interaction in complex diseases: asthmaas an illustrative case
Discussion
13 . Michael Rutter
Conclusions: taking stock and
Autoren-Porträt
Michael Rutter is Professor of Developmental Psychopathology at the Institute of Psychiatry, Kings College London. His research has included the genetics of autism, the effect of early severe deprivation on Romanian orphans adopted into Britain, and the study of both school and environmental influences on childrens behavior. He has published nearly 40 books.
Bibliographische Angaben
- 2008, 1. Auflage, 232 Seiten, Maße: 15,8 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Michael Rutter
- Verlag: Wiley & Sons
- ISBN-10: 047077780X
- ISBN-13: 9780470777800
- Erscheinungsdatum: 30.07.2008
Sprache:
Englisch
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