Glioma Cell Biology
(Sprache: Englisch)
Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem...
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Klappentext zu „Glioma Cell Biology “
Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology. ¿
Inhaltsverzeichnis zu „Glioma Cell Biology “
- Genetic Alterations, Diversity/Heterogneity and Expression Profiling in Gliomas- Epigenetic Changes in Gliomas
- miRNAs in the Pathogenesis of Gliomas
- Signaling Cascades and Transcription Factors Driving the Malginant Phenotype of Glioma Cells
- Glioma Associated Proteases
- Mitochondrially - Mediated Apoptosis in Glioma Cells.-Adhesion Molecules and their Role in Glioma Invasion
- Autophagy in Glioma Cells
- Auto- and Paracrine Mediators in the Glioma Microenvironment
- Glioma Extracellular Matrix
- Autophagy in Glioma Cells
- Glioma Stem Cells and Their Niche
- Immune Response - Glioma Associated Immnosuppression
- Microglia a Friend or Foe?
- Angiogenensis in Gliomas
- Glioma Heterogeneity
- Exprimental Models of Glioma
- Models for the Study of Glioma Cell Invasion
Autoren-Porträt
Aleksi Sedo started his career as a Research Associate at the Institute of Chest Diseases in Prague, Czech Republic in 1987. He subsequently served as a Visiting Scientist and Professor at the Institute of Mutagenesis and Differentiation, which is funded by the Consiglio Nazionala de la Recherche (CNR) in Pisa, Italy. In 1996 he became an Assistant Professor of Biochemistry at the Institute of Medical Chemistry and Biochemistry, 1st Faculty of Medicine, Charles University, Prague and was appointed Associate Professor in 1997. From 1999 to 2002 Professor Sedo was a Senior Scientist at Procter and Gamble in Germany. Today he is a Professor of Medical Chemistry and Biochemistry, Head of the Institute of Biochemistry and Experimental Oncology, and Dean of the 1st Faculty of Medicine, Charles University in Prague.
Bibliographische Angaben
- 2014, 480 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Rolf Mentlein, Aleksi Sedo
- Verlag: Springer Vienna
- ISBN-10: 3709114306
- ISBN-13: 9783709114308
- Erscheinungsdatum: 02.12.2014
Sprache:
Englisch
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