Handbook of Toxicogenomics
A Strategic View of Current Research and Applications
(Sprache: Englisch)
Die Toxikogenomik ist ein neues, dynamisches und viel versprechendes Arbeitsgebiet, das zur Effektivierung toxikologischer Analysen und zur Rationalisierung der Wirkstoffforschung beitragen kann. Interessant ist dieses Thema nicht nur für...
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Die Toxikogenomik ist ein neues, dynamisches und viel versprechendes Arbeitsgebiet, das zur Effektivierung toxikologischer Analysen und zur Rationalisierung der Wirkstoffforschung beitragen kann. Interessant ist dieses Thema nicht nur für Grundlagenforschung und Entwicklung, sondern auch aus juristischer und ethischer Sicht. Fachleute aus allen genannten Bereichen finden in diesem Band fundierte Informationen, zusammengestellt von einem erfahrenen internationalen Autorenteam. Besonders interessant ist dieser interdisziplinär angelegte Überblick für alle, die einschlägige Forschungsstrategien entwickeln müssen.
Klappentext zu „Handbook of Toxicogenomics “
Toxicogenomics promises to speed toxicity analyses, streamline drug development, and improve consumer safety. It is a rapidly evolving field of life sciences research that is highly relevant both for basic and applied research, but also from a regulatory perspective. Researchers and professionals in academia, the pharmaceutical and chemical industry as well as regulatory bodies dealing with toxicogenomics will profit from the information provided here by experienced experts. It will be particularly useful for developing research strategies in this field.The authors are working for major research institutions like the Fraunhofer Institute for Toxicology and Experimental Medicine (Germany), the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Bruker, Bayer, Syngenta, Merck, and Novartis. Coverage spans from the technology platforms applied, like DNA arrays or Proteomics, the bioinformatics tools required, to applications of toxicogenomics presented in numerous case studies and includes also an overview of national programmes and initiatives as well as regulatory perspectives.
Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.
The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.
Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Die Toxikogenomik ist ein neues, dynamisches und viel versprechendes Arbeitsgebiet, das zur Effektivierung toxikologischer Analysen und zur Rationalisierung der Wirkstoffforschung beitragen kann. Interessant ist dieses Thema nicht nur für Grundlagenforschung und Entwicklung, sondern auch aus juristischer Sicht. Fachleute aus allen genannten Bereichen finden in diesem Band fundierte Informationen, zusammengestellt von einem erfahrenen internationalen Autorenteam. Besonders interessant ist dieser interdisziplinär angelegte Überblick für alle, die einschlägige Forschungsstrategien entwickeln müssen.
Walter Rosenthal, Direktor des Forschungsinstituts für Molekulare Pharmakologie in Berlin, lobt das Buch mit den Worten: "Ich möchte zur Herausgabe des Handbuches, das ein höchst aktuelles Thema aufgreift, gratulieren. Es ist gelungen, führende Vertreter dieses Fachgebietes als Autoren zu gewinnen. Das Handbuch zeigt in eindrucksvoller Weise auf, wie moderne Genomforschung zu rasanten Fortschritten und neuen Erkenntnissen in der Toxikologie führt."
The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.
Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Die Toxikogenomik ist ein neues, dynamisches und viel versprechendes Arbeitsgebiet, das zur Effektivierung toxikologischer Analysen und zur Rationalisierung der Wirkstoffforschung beitragen kann. Interessant ist dieses Thema nicht nur für Grundlagenforschung und Entwicklung, sondern auch aus juristischer Sicht. Fachleute aus allen genannten Bereichen finden in diesem Band fundierte Informationen, zusammengestellt von einem erfahrenen internationalen Autorenteam. Besonders interessant ist dieser interdisziplinär angelegte Überblick für alle, die einschlägige Forschungsstrategien entwickeln müssen.
Walter Rosenthal, Direktor des Forschungsinstituts für Molekulare Pharmakologie in Berlin, lobt das Buch mit den Worten: "Ich möchte zur Herausgabe des Handbuches, das ein höchst aktuelles Thema aufgreift, gratulieren. Es ist gelungen, führende Vertreter dieses Fachgebietes als Autoren zu gewinnen. Das Handbuch zeigt in eindrucksvoller Weise auf, wie moderne Genomforschung zu rasanten Fortschritten und neuen Erkenntnissen in der Toxikologie führt."
Inhaltsverzeichnis zu „Handbook of Toxicogenomics “
Introduction TECHNOLOGY PLATFORMS IN TOXICOGENOMICS Expression Profiling Using SAGE and cDNA Arrays Oligo Arrays, Global Transcriptom Analysis Toxicogenomics Applications of Open-Platform High Density DNA Microarrays Mass Spectrometry and Proteomics: Principles and Applications Covalent Protein Modification Analysis by Electrospray Tandem Mass Spectrometry Chromatin Immunoprecipitation-based Identification of Gene Regulatory Networks NMR Spectroscopy as a Versatile Analytical Platform for Toxicology Research
BIOINFORMATIC TOOLS IN TOXICOGENOMICS Generation and Validation of a Reference System for Toxicogenomics DNA Microarray Experiments The Chemical Effects in Biological Systems (CEBS) Knowledge Base Investigating the Effective Range of Agents Using Integrative Modelling Databases and Tools for In-silico Analysis of Regulation of Gene Expression System Biology Applied to Toxicogenomic
APPLICATION OF TOXICOGENOMIC: CASE STUDIES Networks of Liver-enriched Transcription Factors in Liver Biology and Disease Toxicogenomics Applied to Understanding Cholestasis and Steatosis in the Liver Toxicogenomics Applied to Cardiovascular Toxicity Toxicogenomics Applied to Endocrine Disruption Toxicogenomics Applied to Teratogenicity Studies Toxicogenomics Applied to Nephrotoxicity Toxicogenomic Analysis of Human Umbilical Cords to Establish a New Risk Assessment of Human Fetal Exposure to Multiple Chemicals Genetic Variability: Implications for Toxicogenomic Research Profiling of Peripheral Blood Gene Expression to Search for Biomarkers How Things Could Be Done Better Using Toxicogenomics: A Retrospective Analysis Toxicogenomics Applied to Haematotoxicology
THE NATIONAL TOXICOGENOMIC PROGRAM/ INITIATIVES The National Toxicogenomic Program Toxicogenomics: The Japanese Initiative
POINT OF VIEW FROM REGULATORY AUTHORITIES Toxicogenomics in Need for an ICH Guideline? Experiences from the Past
Autoren-Porträt
Jürgen Borlak received a degree in biochemistry and a PhD in biochemical toxicology at the University of Reading, UK, in 1988. He was a Cancer Research Campaign-founded postdoctoral research scientist and in 1990 joined the Marion Merrel Dow Research Institute in Strasbourg, France, as Senior Research Biochemist. In 1998, he was appointed Director of the Center of Drug Research and Molecular Pharmacology at the Fraunhofer Institute of Toxicology and Experimental Medicine; the centre focuses largely on the molecular effects of drugs and xenobiotics, using a wide range of methods and technologies in cell biology, genomics and molecular biology. In 2000 Jürgen Borlak was habilitated in pharmacology and toxicology and received the venia legendi at the Medical School of Hannover. In 2002 he was appointed as full professor to the chair of Pharmaco- and Toxicogenomics at the Medical School of Hannover. He was also appointed as Professor of Molecular Anatomy at the Medical Faculty of the University Leipzig in 2003.Jürgen Borlak is a member of, among others, the Biochemical Society, the Royal Society of Chemistry, the Society of Experimental Biology and the International Society for the Study of Xenobiotics. He is a reviewer for various scientific journals and appointed by the World Health Organisation as an expert on chemical and drug safety.
Bibliographische Angaben
- 2005, 550 Seiten, Gebunden, Englisch
- Herausgegeben: Jürgen Borlak
- Verlag: Wiley-VCH
- ISBN-10: 3527303421
- ISBN-13: 9783527303427
Sprache:
Englisch
Rezension zu „Handbook of Toxicogenomics “
"In summary, the handbook is written by many of the leaders in the field and provides a comprehensive overview of the interdisciplinary field of toxicogenomics. ... both skilled practitioners and those new to the field will find something worthwhile and interesting in this comprehensive handbook." -- ChemBioChem "...one of the few volumes that provide an overview of a field that will increasingly impact us in our daily work, and to which pathologists have a great deal to contribute." -- Veterinary Pathology
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