Hox Genes
(Sprache: Englisch)
The purpose of this book is to argue, and to convince those who may not agree, that the Hox genes are indeed so important that their study will not end with the 20th century. The book is divided into three major sections. The first section covers aspects of...
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The purpose of this book is to argue, and to convince those who may not agree, that the Hox genes are indeed so important that their study will not end with the 20th century. The book is divided into three major sections. The first section covers aspects of the regulation of Hox gene expression and the structure and function of the now justifiably well-known homeobox. The second section offers insights and discussions of the sometimes contentious issues of the origin and evolution of the aforementioned Hox complexes. In the third and last section the role of the resident loci in the specification of body plans and meristic identity of the
arthropods is presented.
arthropods is presented.
Klappentext zu „Hox Genes “
In his 1894 book, Materials for the Study of Variation, William Bateson coined the term Homoeosis with the following prose: The case of the modification of the antenna of an insect into a foot, of the eye of a Crustacean into an antenna, of a petal into a stamen, and the like, are examples of the same kind. It is desirable and indeed necessary that such Variations, which consist in the assumption by one member of a Meristic series, of the form or characters proper to other members of the series, should be recognized as constituting a distinct group of phenomena. ...I therefore propose...the term HOMOEOSIS...; for the essential phenomenon is not that there has merely been a change, but that something has been changed into the likeness of something else. The book was intended as a listing of the kinds of naturally occurring variation that could act as a substrate for the evolutionary process and Bateson took his examples from collections, both private and in museums, of materials displaying morphological oddities. Interestingly the person who also coined the term "Genetics" proffered little in the way of speculation on the possible genetic underpinnings of these oddities. It wasn't until the early part of the next century that these changes in meristic series were shown to be heritable.
Inhaltsverzeichnis zu „Hox Genes “
Section I. Mechanisms of Activity1. Regulation of Hox Activity: Insights from Protein MotifsSamir Merabet, Nagraj Sambrani, Jacques Pradel and Yacine GrabaAbstractIntroductionThe HomeodomainThe Hexapeptide MotifAdditional Hox Functional MotifsConclusion2. Cis?Regulation in the Drosophila Bithorax ComplexRobert K. Maeda and François KarchAbstractGenetics of the Bithorax Complex: The Model of Ed LewisThe BX?C Encodes Only Three Genes, Ubx, abd?A and Abd?BThe Segment?Specific Functions Act as Segment/Parasegment?Specific EnhancersInitiation and Maintenance Phase in BX?C RegulationInitiation, Maintenance and Cell Type?Specific Elements within the Cis?Regulatory DomainThe Cis?Regulatory Regions Are Organized in Segment?SpecificChromosomal DomainsChromatin Boundaries Flank the Parasegment?Specific DomainsElements Mediating Long?Distance Cis- and Trans- Regulatory InteractionsTransvection StudiesPromoter Targeting SequencesPromoter Tethering ElementIntergenic Transcription in the BX?CMicroRNAs in the BX?CConclusion3. Maintenance of Hox Gene Expression PatternsSamantha Beck, Floria Faradji, Hugh Brock and Frédérique PeronnetAbstractIntroductionGenetics of PcG and trxG GenesPcG Proteins and their ComplexesTrxG Proteins and Their ComplexesETP ProteinsPcG and trxG Response ElementsRecruitment of Maintenance Proteins to Maintenance ElementsRole of Maintenance Proteins in Regulation of TranscriptionEpigenetic MarksRelease of PcG SilencingRole of PcG proteins in Chromatin ReplicationRole of PcG Proteins in Stem CellsFuture Research in the Field4. Control of Vertebrate Hox Clusters by Remote and Global Cis?Acting Regulatory SequencesFrançois SpitzAbstractIntroductionColinearity and Clustering of the Homeotic Genes: An Obligatory Functional Link?Vertebrate Hox Clusters are More Clustered Than OthersGlobal Regulation of the Complex through Shared Mechanisms: The Retinoic Acid ConnectionHigh?OrderStructures Over the Complex and ColinearityControl of Vertebrate Hox Genes by Shared
... mehr
Internal EnhancersThe Ins and Outs of Hoxd Gene RegulationThe Role of the Flanking Regions in the Control of Vertebrate Hox GenesControl of the HoxD Cluster through Remote EnhancersRegulation of the HoxD Cluster and More: Global Control Regions and Regulatory LandscapesRemote Enhancers for the Other Vertebrate Hox Clusters?An Evolutionary Success Story and an Increasing Need for a Global RegulationConclusion and Outlook for Hox Gene Regulation in the 21st CenturySection II. Evolution of Hox Genes and Complexes5. The Early Evolution of Hox Genes: A Battle of Belief?Bernd Schierwater and Kai KammAbstractThe Hox SystemPhylogenetic EvidenceOpposing ViewsConclusion6. Evolution of Hox ComplexesDavid E.K. FerrierAbstractIntroductionOrigin of the ProtoHox GeneOrigin of the Hox Cluster from a ProtoHox Cluster, or Not?Expansion and Contraction of the Number of Hox Genes in EvolutionConclusion7. The Nematode Story: Hox Gene Loss and Rapid EvolutionAziz Aboobaker and Mark BlaxterAbstract Introduction: Hox Gene Loss, the Third WayThe Caenorhabditis elegans Hox Cluster, an Extreme Case of Gene LossTracing Hox Gene Loss through the Nematode Phylum: Mode and TempoSea Squirts and Nematodes: Why Do Both Groups Lose Hox GenesHox Gene Loss in FlagranteNematode Hox Gene Function: A Story of Novelty, Conservation and RedeploymentConclusion8. Are the Deuterostome Posterior Hox Genes a Fast?Evolving Clas?Robert LanfearAbstractThe Distribution of the Posterior Hox genes in the MetazoaEarly Duplications of the Posterior Hox GenesThe 'Deuterostome Posterior Flexibility' HypothesisThe Mechanistic Basis of Deuterostome Posterior FlexibilityConclusion and Future DirectionsSection III. Biological Function9. Hox Genes and the Body Plans of Chelicerates and PycnogonidsWim G.M. DamenAbstractArthropods, Mandibulates vs CheliceratesChelicerate Hox
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Autoren-Porträt
JEAN S. DEUT SCH, is Emeritus Professor of Genetics and Animal Biology, Université Pierre et Marie Curie, Paris 6, Department (UMR 7622) "Biologie du Développement". Under the supervision of Prof. P.P. Slonimski, he participated to the birth of mitochondrial genetics of the yeast Saccharomyces cerevisiae. During the '80s, he moved to the Institut Jacques Monod in Paris to study developmental genetics of Drosophila melanogaster, focusing on the genetics of the hormonal control of metamorphosis. In 1993, he was the first in France, together with André Adoutte, to undertake evo-devo studies, choosing the cirripedes, whichhave been Darwin's favourite animals, as a model, because of their so peculiarbody plan. In a second step, his team studied the developmental genetics of other arthropods, including scorpions and pycnogonids. He is author of a number of scientific publications in international journals, and of three textbooks in French on Drosophila and genetics.
Bibliographische Angaben
- 2010, 169 Seiten, 2 farbige Abbildungen, 32 Schwarz-Weiß-Abbildungen, Maße: 17,4 x 26,7 cm, Gebunden, Englisch
- Herausgegeben: Jean S. Deutsch
- Verlag: Landes Bioscience
- ISBN-10: 1441966722
- ISBN-13: 9781441966728
Sprache:
Englisch
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