Immune Dysfunction and Immunotherapy in Heart Disease

PART 1: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes

01 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling

02 Immune Mechanisms In Pediatric Cardiovascular Disease

03 Heart failure - role of autoimmunity

04 Immune basis of Hypertension in Humans

05 Immune Dysregulation: Potential Mediator of Metabolic Syndrome-Induced Cardiac Remodeling

06 T-Helper 2 Cell Cytokines In Remodelling Of Aortic Wall

07 Effects of TNF-alpha on Cardiac Function

08 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy

09 Immunotherapy for left ventricular dysfunction after heart transplantation

PART 2: Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs

10 Immunmodulating therapy in chronic heart failure

11 Statins in Atherosclerosis: Role of Immune Regulation

12 ACE Inhibitors as Immunmodulators: Treatment of Cardiovascular Disease

13 Treatment of Heart Failure by Anticytokine Therapies

PART 3: Immune Dysfunction Leading to Heart Dysfunction: Induction or prevention by Cardiotherapeutic Drugs

14 Pathogenesis Of Cardiovascular Complications In The Acquired Immunodeficiency Syndrome

15 Cytokines and T cell-Mediated Responses in Autoimmune Myocarditis

16 Drugs of abuse: Accentuation of immunomodulation of viral myocarditis

PART 4: Immune Dysfunction Leading to Heart Disease: Induction by Pathogens

17 Osteopontin: The link between the Immune System and cardiac remodeling

18 Inflammatory immune activation in heart failure patients; Therapeutic implications

19 Role of Innate Immune Dysregulation in Diabetic Heart Failure

20 Tolerance in Heart Transplantation: Current and Future Role

21 Neutralization of Th2 cytokines in therapy of cardiovascular pathology

22 Anti-inflammatory immune therapy in heart disease

23 Cholesterol Synthesis, Interleukin 6 inflammation and Atherosclerosis - Role of statins, bisphosphonates and plant

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center's organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.

Ronald Ross Watson Ph.D.

Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749.

(520) 626 2850, Fax (520) 626 6093 rwatson@u.arizona.edu Douglas F. Larson Ph.D.

Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494 dflarson@email.arizona.edu