Immunity and Inflammation in Health and Disease

Section I: Innate and Adaptive Immune Systems: Components and Regulation 1. Innate and Adaptive Immunity: Barriers and Receptor Based Recognition 2. Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns 3. Redox Signaling and Onset of the Inflammatory Cascade

Section II: Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation 4. Reactive Oxygen Species, Oxidative Damage and Cell Death 5. Mitochondrial ROS and T Cell Activation 6. Oxidants and Inflammation: Endothelial Targeting Of Antioxidants to Combat Disease 7. Oxidative Signaling In Chronic Obstructive Airway Diseases

Section III: Inflammatory Systems: Mechanistic Pathways Of Stimulation and Suppression 8. Immune Responses in the Upper Respiratory Tract in Health and Disease 9. The Biological Role of NADPH Oxidases in Pulmonary Ischemia-Reperfusion Injury in Pulmonary Inflammation 10. Receptor Blockade of CD26/DPP4 as a Therapeutic Strategy Against I/R Injury and Lymphocytic Inflammation And Its Clinical Implications 11. DPPIV/CD26 as A Target in Anti-Inflammatory Therapy 12. Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of Inflammation

Section IV: Immunity and Inflammation: Common Threads Of Multifactorial Diseases 13. Monogenic Defects of Toll-Loke receptor Signaling and Primary Immunodeficiency 14. PPAthogen - and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) in the Innate Immune Response in Crohn's Disease 15. Inflammation and Calcification in the Vascular Tree; Insights into Atherosclerosis 16. From Inflammation to Cancer: Opportunites for Chemoprevention via Dietary Intervention 17. Inflammation in Bullous Pemphigoid, a Skin Auto-Immune Disease 18. Inflammation in Systemic Immune Diseases: Role of TLR9 Signaling and the Resultant Oxidative Stress in Pathology of Lupus

Dr. Shampa Chatterjee received her PhD in Chemistry from the Indian Institute of Technology (Bombay) in 1997. Her research interests are in the field of reactive oxygen species (ROS) and redox biology as it relates to inflammation. Her lab studies the effect of ROS generated by the vascular wall in onset of inflammation. Toward this, work from her group shows that signals emanating from the wall of blood vessels are the earliest stimuli for the onset and amplification of inflammation. The topics addressed in this book are thus central to her research where she tries to unravel the balance between host defense and inflammation induced damage.



Currently, Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology (American Journal of Physiology: Lung Cellular and Molecular Physiology, Pulmonary Circulation and Jacobs Journal of Physiology). She has published more than 50 papers in peer reviewed journals. She has also received numerous awards such as the Carolin Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology in 2015. Wolfgang Jungraithmayr MD, PhD is a transplant surgeon and immunologist with a research interest in the field of transplant and tumor immunology. His lab has unraveled some of the signaling events that follow the transplant procedure and that lead to allograft rejection post lung transplant. He is professor of thoracic surgery at the University of Zurich, Switzerland, and the Medical University Brandenburg, Germany. Wolfgang Jungraithmayr published more than 70 original articles and received several awards, among them the Grillo Award of the European Society of Thoracic Surgeons Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer