In vivo Models for Drug Discovery
(Sprache: Englisch)
How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development as well as the scientific and regulatory pitfalls along the path to success.
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How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development as well as the scientific and regulatory pitfalls along the path to success.
Klappentext zu „In vivo Models for Drug Discovery “
This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases.Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges.Key knowledge for drug researchers in industry as well as academia.
Inhaltsverzeichnis zu „In vivo Models for Drug Discovery “
PrefacePART I: Transversal Issues Concerning Animal Models in Drug DiscoveryTHE 3Ns OF PRECLINICAL ANIMAL MODELS IN BIOMEDICAL RESEARCHFirst N: The Need for Use of Animal ModelsSecond N: The Need for Better Animal ModelsThird N: The Need for 3Rs Guiding PrinciplesALTERNATIVE MODELS IN DRUG DISCOVERY AND DEVELOPMENT PART I: IN SILICO AND IN VITRO MODELSIntroductionIn Silico ModelsIn Vitro ModelsALTERNATIVE MODELS IN DRUG DISCOVERY AND DEVELOPMENT PART II: IN VIVO NONMAMMALIAN AND EXPLORATORY/EXPERIMENTAL HUMAN MODELSIntroductionIn Vivo Nonmammalian ModelsIn Vivo Exploratory and Experimental Human ModelsETHICAL ISSUES AND REGULATIONS AND GUIDELINES CONCERNING ANIMAL RESEARCHIntroductionCurrent Use of Animals in Biomedical and Pharmaceutical ResearchEhtical Concerns and Positions on Animal ResearchGeneral Principles for the Ethical Use of Animals in ResearchRegulatory Framework for Use of Animals in ResearchREGULATORY ISSUES: SAFETY AND TOXICOLOGY ASSESSMENTIntroductionAnimal Species in Toxicology StudiesToxicology StudiesTranslation to Clinics: Limitations and DifficultiesGENERATION AND USE OF TRANSGENIC MICE IN DRUG DISCOVERYIntroductionImproved Mouse Genetic EngineeringFunctional Evaluation and Uses of Mouse ModelsTranslation to Clinics: Limitations and DifficultiesPerspectivesIN VIVO BRAIN IMAGING IN ANIMAL MODELS: A FOCUS ON PET AND MRIIntroduction: Role of Animal in In Vivo ImagingThe Choice of the Right Imaging Modality for Brain ImagingSmall Animal Magnetic Resonance ImagingPositron Emission TomographyClinical Translation: Limitations and DifficultiesPART II: Animal Models in Specific Disease Areas of Drug DiscoverySUBSTANCE ABUSE AND DEPENDENCEIntroductionDifficulties to Model Addiction in AnimalsTolerance, Sensitization, and Physical WithdrawalReward and ReinforcementTranslation to Clinics: Limitations and DifficultiesMOOD AND ANXIETY DISORDERSIntroductionAnimal Models of Anxiety DisordersAnimal Models of Mood DisordersTranslation to Clinics: Limitations and
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DifficultiesSCHIZOPHRENIAIntroductionModels Amenable to Use in ScreeningTranslation to Clinics: Limitations and DifficultiesMIGRAINE AND OTHER HEADACHESIntroductionVascular ModelsNeurogenic InflammationNociceptive Activation of the Trigeminovascular SystemCortical Spreading DepressionHuman Experimental Migraine Provoking ModelsAnimal Experimental Migraine Provoking ModelsTransgenic ModelsBehavioral ModelsTranslation to Clinics: Limitations and DifficultiesNOCICEPTIVE, VISCERAL, AND CANCER PAINIntroductionAcute Pain TestsVisceral Pain ModelsCancer Pain ModelsTranslation to Clinics: Limitations and DifficultiesINFLAMMATORY, MUSCULOSKELETAL/JOINT (OA AND RA), AND POSTOPERATIVE PAINIntroduction: Evaluation of Pain in Animal ModelsInflammatory PainMusculoskeletal/Joint Osteoarthritis (OA) and Rheumatoid Arthritis (RA) PainPostoperative PainTranslation to Clinics: Limitations and DifficultiesNEUROPATHIC PAINIntroductionMain Types of Neuropathic Pain in HumansModelization of Chronic Pain in RodentsTranslation to Clinics: Limitations and DifficultiesOBESITY AND METABOLIC SYNDROMEIntroductionWhy Metabolic Syndrome?Classical Animal Models of Obesity and Metabolic SyndromeHuman Experimental ModelsTranslation to Clinics: Limitations and DifficultiesCOGNITIVE DISORDERS: IMPAIRMENT, AGING, AND DEMENTIAIntroductionPharmacological ModelsAging and Transgenic ModelsTranslation to Clinics: Limitations and DifficultiesSTROKE AND TRAUMATIC BRAIN INJURYIntroductionStroke ModelsTraumatic Brain Injury ModelsTranslation to Clinics: Limitations and DifficultiesMOVEMENT DISORDERS: PARKINSON'S DISEASEIntroductionDrug- and Toxin-Based Models of PDGenetic and Functional Models of PDTranslation to Clinics: Limitations and DifficultiesEPILEPSY: ANIMAL MODELS TO REPRODUCE HUMAN ETIOPATHOLOGYIntroductionWhat Animal Species to Use to Model Epilepsy?Which Type of Models Provide the Most Reliable Information on the Pathophysiology of Epilepsies?Modeling Four Prototypic Forms of EpilepsyTranslation to Clinics: Limitations and DifficultiesLUNG DISEASESIntroductionAnimal Models of Lung Emphysema or Chronic Obstructive Pulmonary DiseaseAnimal Models of Pulmonary HypertensionAnimal Models of Fibrotic Lung DiseasesAnimal Models of Acute Respiratory Distress SyndromeTranslation to Clinics: Limitations and DifficultiesHEART FAILUREIntroductionHypertension-Related Heart FailurePressure and Volume Overload-Induced Heart FailureToxic Molecule-Induced Heart FailureHeart Failure Models Related to Myocardial Ischemia and/or Myocardial InfarctionPacing-Induced Heart FailureGene Mutation-Induced CardiomyopathiesTranslation to Clinics: Limitations and DifficultiesENDOCRINE DISORDERSIntroductionAnimal Models in Autoimmune Endocrine DiseasesAnimal Models in Endocrine TumorsAnimal Models in Endocrine Physiology: Organogenesis, Reproduction; and MetabolismTranslation to Clinics: Limitations and DifficultiesGASTROINTESTINAL DISORDERS: A PATHO-BIOTECHNOLOGY APPROACH TO PROBIOTIC THERAPYIntroducctionDelivery: Improving Probiotic Resistance to Process-Induced Stresses and Storage ConditionsSurvival: Improving Probiotic-Host ColonizationEfficacy: "Designer Probiotics"Translation to Clinics: Limitations and DifficultiesRENAL DISORDERSIntroductionAnimal ModelsTranslation to Clinics: Limitations and DifficultiesGENITOURINARY DISORDERS: LOWER URINARY TRACT AND SEXUAL FUNCTIONSIntroductionLower Urinary Tract FunctionSexual FunctionsTranslation to Clinics: Limitations and DifficultiesIndex
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Autoren-Porträt
Jose Miguel Vela obtained his PhD at the Autonomous University of Barcelona (UAB). He was working as a faculty member engaged in both teaching and research at the Department of Cell Biology, Physiology and Immunology of the UAB. In 2003 he joined ESTEVE R&D as Head of Target Validation, was then Director of Pharmacology, and currently is the Head of Drug Discovery and Preclinical Development. Starting as a neurobiologist he progressed as a neuropharmacologist. His current research is focused on the discovery and development of new analgetics. He has authored more than 100 scientific publications and 80 patent applications.Rafael Maldonado is Professor of Pharmacology at the University Pompeu Fabra in Barcelona (Spain), where he founded the Laboratory of Neuropharmacology. His research is focused on the study of the neurochemical basis of drug dependence and related disorders, including affective, pain and eating disorders, with a particular focus on the development of novel behavioral models. He has published over 250 scientific articles in international journals and he has been Principal Investigator for 20 years of research grants funded by the main French, Spanish, European, and USA agencies. He is also member of the editorial board of several scientific journals, and has also collaborated with public authorities and private companies in the research policy and pharmaceuticals development on drug abuse and pain.Michel Hamon is Professor of Neuropharmacology at the University Pierre and Marie Curie in Paris (France). He founded and led a Neuropsychopharmacology Unit of the French Institute for Health and Medical Research (INSERM) at the Faculty of Medicine Pitié-Salpêtrière, with the focus on neurobiological mechanisms underlying key brain functions (nociception, sleep, neurovegetative regulations) and behavioral controls by using validated animal models. He has published more than 600 scientific articles. He edited 6 books, and was president of the French
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Society for Neuroscience and executive officer of the European College of Neuropsychopharmacology (ECNP).
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Bibliographische Angaben
- 2014, 594 Seiten, 8 farbige Abbildungen, 27 Schwarz-Weiß-Abbildungen, Maße: 17,7 x 24,6 cm, Gebunden, Englisch
- Herausgegeben: José Miguel Vela, Rafael Maldonado, Michel Hamon, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
- Verlag: Wiley-VCH
- ISBN-10: 3527333282
- ISBN-13: 9783527333288
- Erscheinungsdatum: 24.06.2014
Sprache:
Englisch
Pressezitat
"I also found it to be a great resource for teaching." ( ChemMedChem , 1 January 2015)Kommentar zu "In vivo Models for Drug Discovery"
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