Introduction to Computational Biology
An Evolutionary Approach
(Sprache: Englisch)
Written with the advanced undergraduate in mind, this book introduces into the field of Bioinformatics. The authors explain the computational and conceptional background to the analysis of large-scale sequence data. Many of the corresponding analysis...
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Produktinformationen zu „Introduction to Computational Biology “
Klappentext zu „Introduction to Computational Biology “
Written with the advanced undergraduate in mind, this book introduces into the field of Bioinformatics. The authors explain the computational and conceptional background to the analysis of large-scale sequence data. Many of the corresponding analysis methods are rooted in evolutionary thinking, which serves as a common thread throughout the book. The focus is on methods of comparative genomics and subjects covered include: alignments, gene finding, phylogeny, and the analysis of single nucleotide polymorphisms (SNPs). The volume contains exercises, questions & answers to selected problems.
Inhaltsverzeichnis zu „Introduction to Computational Biology “
- Introduction- The Drosophila Project
Part I: Analysis of Similarities in Homologous Sequences
- Optimal Pairwise Alignment
- Fast Database Searching
- Strings and the Exact Matching Problem
- Sequence Profiles and Hidden Markov Models
- What is a Gene?- Multiple Alignments and Phylogenesis
Part II: Analysis of Dissimilarities in Homologous Sequences
- Sequence Polymorphism and Divergence
- Coalescence Theory and Simulating Sequence Evolution
- Non-Neutral Evolution and Mathematical Modelling
- Testing Evolutionary Hypothesis
- An Application: Gene Mapping by Linkage Disequilibrium
- Outlook
- The 5th Nucleotide.
Bibliographische Angaben
- Autoren: Bernhard Haubold , Thomas Wiehe
- 2007, 328 Seiten, Maße: 17,2 x 24,2 cm, Gebunden, Englisch
- Verlag: Springer
- ISBN-10: 3764367008
- ISBN-13: 9783764367008
Sprache:
Englisch
Rezension zu „Introduction to Computational Biology “
From the reviews: "Haubold and Weihe is precisely addressed to this increasingly large circle of people using sequences ... an introduction to the computational aspects of genomics and the interpretation of sequence biological data. ... Each chapter ends with a small section of interesting exercises and accompanying answers ... . These make the book very useful for students in bioinformatics but also for researchers and students in molecular biology, genetics, medicine or at the other end students in computer sciences or mathematics interested in molecular biology." (Andrei Petrescu, Romanian Journal of Biochemistry, Vol. 47 (1), 2010)
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