Judah Folkman

Biographic profile Development of assays to study angiogenesis 2.1.The rabbit cornea 2.2.The chorioallantoic membrane              2.3       Culture of endothelial cells 3. Tumor angiogenesis 3.1. Early evidence that tumor cells release specific growth factors for endothelial cells 3.2. Absence of angiogenesis in tumors in isolated perfused organs 3.3. Tumor growth is angiogenesis-dependent 3.4. The concept of angiogenic switch 3.5. The avascular and vascular phases of solid tumor growth 3.6. Angiogenesis and metastasis 3. 7. Prognostic significance of tumor vascularity 4. The discovery of angiogenic factors 4.1. Isolation of the first tumor angiogenesis factor 4.2. The discovery of FGF 4.3. The discovery of VPF/VEGF 5. Anti-angiogenesis             5.1. Inhibition of angiogenesis by a diffusible factor from cartilage 5.2. Endogenous, direct and indirect inhibitors 5.3. Inteferon alpha             5.4. Platelet factor 4/Protamine             5.5. Angiostatic steroids             5.6. Fumagillin             5.7. Angiostain and endostatin             5.8. Thalidomide 5.9. 2-methoxyestradiol and cleaved antithrombin III            5.10. Anti-angiogenic chemotherapy 6. Concluding remarks 7. References 8. Publications of Judah Folkman (2014-1956)