Medical Genomics
(Sprache: Englisch)
An up to date edition of the groundbreaking classic Medical genomics is rapidly moving into mainstream medicine, with new and emerging technologies such as molecular genetic diagnostic tests and gene therapy having an unprecedented impact in clinical practice.
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An up to date edition of the groundbreaking classic Medical genomics is rapidly moving into mainstream medicine, with new and emerging technologies such as molecular genetic diagnostic tests and gene therapy having an unprecedented impact in clinical practice.
Klappentext zu „Medical Genomics “
An up-to-date edition of the groundbreaking classicMedical genomics is rapidly moving into mainstream medicine, with new and emerging technologies such as molecular genetic diagnostic tests and gene therapy having an unprecedented impact in clinical practice. Consequently, there is an urgent need for physicians and medical students to understand these developments and their evolving roles in the post-genomics era. This book fills that important need with a practical, comprehensive introduction to genomics with a focus on its impact on medical research and practice.
This valuable new edition has been thoroughly and meticulously updated and expanded to include the most exciting and up-to-the-minute topics in biomedical research, including all-new chapters on multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays. It also includes thoroughly revised coverage of topics from the previous edition, including molecular biology, biotechnology, genome databases, bioinformatics tools, human genetic variation, genetic testing, gene therapy, microarray and related gene expression technology, analysis of microarray data, pharmacogenomics and toxico-genomics, clinical research informatics, alternative splicing, cancer genomics, proteomics, consumer genomics, and genetic data privacy and ethics.
Covering concepts and techniques that are currently in use, as well as those on the cutting-edge of science, Essentials of Medical Genomics, Second Edition gives physicians and medical students everything they need to know about genomics and emerging technologies. Now 50% more comprehensive than the previous edition, and complemented with useful exercises and an appendix, this Second Edition is truly the most useful handbook available.
Inhaltsverzeichnis zu „Medical Genomics “
Preface1 Introduction to Molecular Genetics
The Principles of Inheritance
Genes Are Made of DNA
DNA Structure
The Central Dogma
References
2 Molecular Biology Technology
Cut, Copy, and Paste
Restriction Enzymes
DNA Cloning Is Copying
PCR Is Cloning without the Bacteria
DNA Sequencing
References
3 Genome Databases
Genome Sequencing
Entrez
BLAST
Genome Annotation
Genome Browser
Human Genetic Diseases
A System for Naming Genes
Model Organisms (Comparative Genomics)
Sequencing Other Genomes
References
4 Bioinformatics Tools
Patterns and Tools
Sequence Comparison
Multiple Alignment
Pattern Finding
Phylogenetics
Biotechnology Exercise
References
5 Human Genetic Variation
Mutation
Single-Nucleotide Polymorphisms
Linkage
Multigene Diseases
Genetic Testing
SNP Chips
The HapMap Project
Research Uses of SNP Markers
Ethnicity and Genome Diversity
References
6 Genetic Testing for the Practitioner (Harry Ostrer)
Clinical Applications of Genetic Testing
Methods of Genetic Testing
Adequacy of Genetic Testing
Informed Consent
Genetic Counseling
Clinical Vignettes
References
7 Gene Therapy (John G. Hay)
Historical Perspective
Strategies of Gene Therapy
DNA Elements for Gene Expression
Gene Delivery Systems
Targeting Gene Delivery
Formative Years and Initial Clinical Approaches
The Problems
The Future
References
8 Microarrays
Spotting versus Synthesis on the Chip
Other Types of Arrays
Differential Gene Expression
Error and Reliability
Evolutionary Perspectives
References
9 Analysis of Microarray Data
Experimental Design
Data Analysis Workflow
Functional Analysis
Validation
References
10 Pharmacogenomics and Toxicogenomics
Pharmacogenomics
Environmental Chemicals
Toxicogenomics for Drug Development
References
11 Clinical Research
... mehr
Informatics
Clinical Databases
Clinical Trials Management
Data Standards and Ontologies
Tissue Banks
Application to Medical Practice
References
12 RNA Interference and MicroRNAs
Antisense RNA
RNA Interference
Ribozymes
References
13 Alternative Splicing
Exon Arrays
Medical Applications of Alternative Splicing
References
14 Genome Tiling Chips
Genome Chips
Resequencing Chips
Whole-Genome Transcription Profilig
ChIP-chip
ArrayCGH
References
15 Cancer Genomics
Understanding Cancer Genomics
Copy Number Mutations
Gene Expression Signatures
Cancer Genome Atlas
References
16 Proteomics
Protein Modifications
Quantitative Approaches
Biomarkers
Protein Databases
Protein-Protein Interactions
DNA-Binding Proteins
Structural Proteomics
Drug Targets
References
17 Consumer Genomics and Genealogy
Genealogy
Nutrigenomics
Privacy Concerns
References
18 The Ethics of Medical Genomics
Eugenics
Human Genome Diversity Project and Population Genetics
Genetic Discrimination
Impact on Physicians and Researchers
Clinical Research
References
Appendix: Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata)
Glossary
Index
Clinical Databases
Clinical Trials Management
Data Standards and Ontologies
Tissue Banks
Application to Medical Practice
References
12 RNA Interference and MicroRNAs
Antisense RNA
RNA Interference
Ribozymes
References
13 Alternative Splicing
Exon Arrays
Medical Applications of Alternative Splicing
References
14 Genome Tiling Chips
Genome Chips
Resequencing Chips
Whole-Genome Transcription Profilig
ChIP-chip
ArrayCGH
References
15 Cancer Genomics
Understanding Cancer Genomics
Copy Number Mutations
Gene Expression Signatures
Cancer Genome Atlas
References
16 Proteomics
Protein Modifications
Quantitative Approaches
Biomarkers
Protein Databases
Protein-Protein Interactions
DNA-Binding Proteins
Structural Proteomics
Drug Targets
References
17 Consumer Genomics and Genealogy
Genealogy
Nutrigenomics
Privacy Concerns
References
18 The Ethics of Medical Genomics
Eugenics
Human Genome Diversity Project and Population Genetics
Genetic Discrimination
Impact on Physicians and Researchers
Clinical Research
References
Appendix: Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata)
Glossary
Index
... weniger
Autoren-Porträt von Stuart M. Brown, John G. Hay, Harry Ostrer
STUART M. BROWN, PhD, is on the faculty of the New York University School of Medicine, where he is Associate Professor and Director of the Bioinfor-matics Core Facility and Director of the graduate Bioinformatics course.
Bibliographische Angaben
- Autoren: Stuart M. Brown , John G. Hay , Harry Ostrer
- 2008, 2. Aufl., 448 Seiten, Maße: 15,7 x 24,1 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0470140194
- ISBN-13: 9780470140192
- Erscheinungsdatum: 14.11.2008
Sprache:
Englisch
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